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Gene Review

EMP3  -  epithelial membrane protein 3

Homo sapiens

Synonyms: EMP-3, Epithelial membrane protein 3, HNMP-1, Hematopoietic neural membrane protein 1, Protein YMP, ...
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Disease relevance of EMP3


High impact information on EMP3


Biological context of EMP3


Anatomical context of EMP3

  • The levels of EMP-3 transcripts are highest in peripheral blood leukocytes, ovary, intestine and various embryonic tissues [6].
  • In the fiber tracts of the spinal cord and in sciatic nerve, HNMP-1 protein is axon-associated [3].

Other interactions of EMP3


Analytical, diagnostic and therapeutic context of EMP3

  • We first investigated the transcript level of EMP3 in a cohort of 57 OTs by quantitative real-time RT-PCR [5].


  1. EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastoma. Alaminos, M., Dávalos, V., Ropero, S., Setién, F., Paz, M.F., Herranz, M., Fraga, M.F., Mora, J., Cheung, N.K., Gerald, W.L., Esteller, M. Cancer Res. (2005) [Pubmed]
  2. A second locus for an axonal form of autosomal recessive Charcot-Marie-Tooth disease maps to chromosome 19q13.3. Leal, A., Morera, B., Del Valle G, n.u.l.l., Heuss, D., Kayser, C., Berghoff, M., Villegas, R., Hernández, E., Méndez, M., Hennies, H.C., Neundörfer, B., Barrantes, R., Reis, A., Rautenstrauss, B. Am. J. Hum. Genet. (2001) [Pubmed]
  3. HNMP-1: a novel hematopoietic and neural membrane protein differentially regulated in neural development and injury. Bolin, L.M., McNeil, T., Lucian, L.A., DeVaux, B., Franz-Bacon, K., Gorman, D.M., Zurawski, S., Murray, R., McClanahan, T.K. J. Neurosci. (1997) [Pubmed]
  4. The H4b minor histocompatibility antigen is caused by a combination of genetically determined and posttranslational modifications. Yadav, R., Yoshimura, Y., Boesteanu, A., Christianson, G.J., Ajayi, W.U., Shashidharamurthy, R., Stanic, A.K., Roopenian, D.C., Joyce, S. J. Immunol. (2003) [Pubmed]
  5. EMP3 overexpression is associated with oligodendroglial tumors retaining chromosome arms 1p and 19q. Li, K.K., Pang, J.C., Chung, N.Y., Ng, Y.L., Chan, N.H., Zhou, L., Poon, W.S., Ng, H.K. Int. J. Cancer (2007) [Pubmed]
  6. Epithelial membrane protein-2 and epithelial membrane protein-3: two novel members of the peripheral myelin protein 22 gene family. Taylor, V., Suter, U. Gene (1996) [Pubmed]
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