High impact information on LTV1

• The complex contains two small GTPases (Gtr1p and Gtr2p) and three other proteins (Ybr077c, Ykr007w and Ltv1p) that are located in the late endosomal membrane [1].
• Finally, we show a genetic interaction between LTV1 and YRB2, a gene that encodes a Ran-GTP-, Crm1-binding protein that facilitates the small subunit export [2].
• Ltv1 Is Required for Efficient Nuclear Export of the Ribosomal Small Subunit in Saccharomyces cerevisiae [2].
• Ltv1 interacts with Crm1, co-sediments in sucrose gradients with 43S/40S subunits, and copurifies with late 43S particles [2].
• Ltv1 is a nonessential, nonribosomal protein that is required for 40S subunit biogenesis in yeast [2].

Biological context of LTV1

• We provide genetic and biochemical evidence that Yar1, a small ankyrin-repeat protein, physically interacts with RpS3, a component of the 40S subunit, and with Ltv1, a protein recently identified as a substoichiometric component of a 43S preribosomal particle [3].
• We propose that Ltv1 functions as one of several possible adapter proteins that link the nuclear export machinery to the small subunit [2].

Anatomical context of LTV1

• We demonstrate that cells lacking YAR1 or LTV1 are hypersensitive to particular protein synthesis inhibitors and exhibit aberrant polysome profiles, with a reduced absolute number of 40S subunits and an excess of free 60S subunits [3].

Other interactions of LTV1

• We propose that YAR1 and LTV1 play distinct, nonessential roles in 40S subunit production [3].

References