Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

GLG1 - glycogenin glucosyltransferase GLG1

Saccharomyces cerevisiae S288c

Synonyms: Glycogen synthesis initiator protein 1, Glycogenin glucosyltransferase 1, Glycogenin-1, YKR058W

Cheng, C. et al., Albrecht, T. et al.

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High impact information on GLG1

Yeast cells defective in either GLG1 or GLG2 are similar to the wild type in their ability to accumulate glycogen [1].
The activation state of glycogen synthase in glg1 glg2 cells is suppressed, suggesting that the Glg proteins may additionally influence the phosphorylation state of glycogen synthase [1].

Biological context of GLG1

We report the identification of two Saccharomyces cerevisiae genes, GLG1 and GLG2, whose products are implicated in the biogenesis of glycogen [1].

Associations of GLG1 with chemical compounds

Saccharomyces cerevisiae possesses two glycogenin isoforms (designated as Glg1p and Glg2p) that both contain a conserved tyrosine residue, Tyr232 [2].

References

Requirement of the self-glucosylating initiator proteins Glg1p and Glg2p for glycogen accumulation in Saccharomyces cerevisiae. Cheng, C., Mu, J., Farkas, I., Huang, D., Goebl, M.G., Roach, P.J. Mol. Cell. Biol. (1995) [Pubmed]
Yeast glycogenin (Glg2p) produced in Escherichia coli is simultaneously glucosylated at two vicinal tyrosine residues but results in a reduced bacterial glycogen accumulation. Albrecht, T., Haebel, S., Koch, A., Krause, U., Eckermann, N., Steup, M. Eur. J. Biochem. (2004) [Pubmed]

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