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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TIF1  -  translation initiation factor eIF4A

Saccharomyces cerevisiae S288c

 
 
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High impact information on TIF1

  • Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1 [1].
  • We describe the isolation and characterization of two previously undescribed genes, TIF1 and TIF2, from Saccharomyces cerevisiae [2].
  • We report isolation of CES1 in a separate screen for high copy suppression of a temperature-sensitive mutation (A79V) of the yeast translation initiation factor Tif1p (eIF-4A) [3].
 

Biological context of TIF1

  • An essential yeast protein, encoded by duplicated genes TIF1 and TIF2 and homologous to the mammalian translation initiation factor eIF-4A, can suppress a mitochondrial missense mutation [2].
  • Yeast Saccharomyces cerevisiae genes TIF1 and TIF2 (translation initiation factor) encode a protein tentatively called translation initiation factor (Tif) due to the similarity of its amino acid sequence and its molecular weight to mammalian eukaryotic initiation factor 4A [4].
 

Regulatory relationships of TIF1

  • Analysis of the expression of eIF-4A-beta-galactosidase fusion proteins reveals that the TIF2 gene is more highly expressed than the TIF1 gene [5].

References

  1. Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1. vom Baur, E., Zechel, C., Heery, D., Heine, M.J., Garnier, J.M., Vivat, V., Le Douarin, B., Gronemeyer, H., Chambon, P., Losson, R. EMBO J. (1996) [Pubmed]
  2. An essential yeast protein, encoded by duplicated genes TIF1 and TIF2 and homologous to the mammalian translation initiation factor eIF-4A, can suppress a mitochondrial missense mutation. Linder, P., Slonimski, P.P. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  3. Effects of deletion mutations in the yeast Ces1 protein on cell growth and morphology and on high copy suppression of mutations in mRNA capping enzyme and translation initiation factor 4A. Schwer, B., Linder, P., Shuman, S. Nucleic Acids Res. (1998) [Pubmed]
  4. Translation in Saccharomyces cerevisiae: initiation factor 4A-dependent cell-free system. Blum, S., Mueller, M., Schmid, S.R., Linder, P., Trachsel, H. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  5. Expression of translation initiation factor 4A from yeast and mouse in Saccharomyces cerevisiae. Prat, A., Schmid, S.R., Buser, P., Blum, S., Trachsel, H., Nielsen, P.J., Linder, P. Biochim. Biophys. Acta (1990) [Pubmed]
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