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Gene Review

EIF4A1  -  eukaryotic translation initiation factor 4A1

Homo sapiens

Synonyms: ATP-dependent RNA helicase eIF4A-1, DDX2A, EIF-4A, EIF4A, Eukaryotic initiation factor 4A-I, ...
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Disease relevance of EIF4A1


High impact information on EIF4A1


Other interactions of EIF4A1

  • Exhibiting DEAD-box motifs characteristic for RNA helicases, hNMP 265 is highly similar to the human initiation factors eIF4A-I and -II [5].


  1. The human eukaryotic initiation factor 4AI gene (EIF4A1) contains multiple regulatory elements that direct high-level reporter gene expression in mammalian cell lines. Quinn, C.M., Wiles, A.P., El-Shanawany, T., Catchpole, I., Alnadaf, T., Ford, M.J., Gordon, S., Greaves, D.R. Genomics (1999) [Pubmed]
  2. A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery. Marcotrigiano, J., Lomakin, I.B., Sonenberg, N., Pestova, T.V., Hellen, C.U., Burley, S.K. Mol. Cell (2001) [Pubmed]
  3. Mutually cooperative binding of eukaryotic translation initiation factor (eIF) 3 and eIF4A to human eIF4G-1. Korneeva, N.L., Lamphear, B.J., Hennigan, F.L., Rhoads, R.E. J. Biol. Chem. (2000) [Pubmed]
  4. Nucleotide sequence of human cDNA encoding eukaryotic initiation factor 4AI. Kim, N.S., Kato, T., Abe, N., Kato, S. Nucleic Acids Res. (1993) [Pubmed]
  5. A human common nuclear matrix protein homologous to eukaryotic translation initiation factor 4A. Holzmann, K., Gerner, C., Pöltl, A., Schäfer, R., Obrist, P., Ensinger, C., Grimm, R., Sauermann, G. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
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