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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TFA2  -  Tfa2p

Saccharomyces cerevisiae S288c

Synonyms: Factor A 43 kDa subunit, TFIIE-beta, Transcription factor A small subunit, Transcription initiation factor IIE subunit beta, YKR062W
 
 
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High impact information on TFA2

  • Saccharomyces cerevisiae Gal11, a component of the holoenzyme of RNA polymerase II, interacts through its functional domains A and B with the small (Tfa2) and large (Tfa1) subunits of the general transcription factor (TF) IIE, respectively [1].
 

Biological context of TFA2

  • The deduced amino acid sequences of the TFA1 and TFA2 gene products were homologous to those of the large and small subunits of human TFIIE, respectively, identifying factor a as the yeast homolog of TFIIE [2].
 

Associations of TFA2 with chemical compounds

  • Here we demonstrate that the C-terminal basic region in Tfa2 is responsible for binding to domain A, whereas both the N-terminal hydrophobic and internal glutamic acid-rich regions in Tfa1 are responsible for binding to domain B [3].
 

Other interactions of TFA2

  • Genes encoding both the 66- and the 43-kDa subunits of yeast RNA polymerase II initiation factor a, designated TFA1 and TFA2, have been isolated [2].

References

  1. Functional correlation among Gal11, transcription factor (TF) IIE, and TFIIH in Saccharomyces cerevisiae. Gal11 and TFIIE cooperatively enhance TFIIH-mediated phosphorylation of RNA polymerase II carboxyl-terminal domain sequences. Sakurai, H., Fukasawa, T. J. Biol. Chem. (1998) [Pubmed]
  2. Yeast TFIIE. Cloning, expression, and homology to vertebrate proteins. Feaver, W.J., Henry, N.L., Bushnell, D.A., Sayre, M.H., Brickner, J.H., Gileadi, O., Kornberg, R.D. J. Biol. Chem. (1994) [Pubmed]
  3. Yeast Gal11 and transcription factor IIE function through a common pathway in transcriptional regulation. Sakurai, H., Fukasawa, T. J. Biol. Chem. (1997) [Pubmed]
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