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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PET127  -  Pet127p

Saccharomyces cerevisiae S288c

Synonyms: OR26.07, YOR017W
 
 
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High impact information on PET127

  • Epitope-tagged Pet127p was specifically located in mitochondria and associated with membranes [1].
  • However, cytochrome b protein is not synthesized, and thus the Delta cbp1 Delta pet127 strain does not respire [2].
  • The second new suppressor gene described here, PET127, encodes a protein too large (M(r) 95900) to be a ribosomal protein and appears to operate by a different mechanism [3].
  • Yeast nuclear PET127 gene can suppress deletions of the SUV3 or DSS1 genes: an indication of a functional interaction between 3' and 5' ends of mitochondrial mRNAs [4].
 

Anatomical context of PET127

  • These findings suggest that Pet127p plays a role in RNA surveillance and/or RNA processing and that these functions may be membrane bound in yeast mitochondria [1].

References

  1. Pet127p, a membrane-associated protein involved in stability and processing of Saccharomyces cerevisiae mitochondrial RNAs. Wiesenberger, G., Fox, T.D. Mol. Cell. Biol. (1997) [Pubmed]
  2. Cbp1 is required for translation of the mitochondrial cytochrome b mRNA of Saccharomyces cerevisiae. Islas-Osuna, M.A., Ellis, T.P., Marnell, L.L., Mittelmeier, T.M., Dieckmann, C.L. J. Biol. Chem. (2002) [Pubmed]
  3. Suppression of carboxy-terminal truncations of the yeast mitochondrial mRNA-specific translational activator PET122 by mutations in two new genes, MRP17 and PET127. Haffter, P., Fox, T.D. Mol. Gen. Genet. (1992) [Pubmed]
  4. Yeast nuclear PET127 gene can suppress deletions of the SUV3 or DSS1 genes: an indication of a functional interaction between 3' and 5' ends of mitochondrial mRNAs. Wegierski, T., Dmochowska, A., Jabłonowska, A., Dziembowski, A., Bartnik, E., Stepień, P.P. Acta Biochim. Pol. (1998) [Pubmed]
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