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Gene Review

LEO1  -  Leo1p

Saccharomyces cerevisiae S288c

Synonyms: O3278, RNA polymerase-associated protein LEO1, YOR123C, YOR3278C
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High impact information on LEO1

  • In addition, we independently isolated paf1 and leo1 mutations in an unbiased genetic screen for suppressors of a cold-sensitive spt5 mutation [1].
  • Remarkably, deletion of LEO1 or RTF1 suppresses many paf1Delta phenotypes [2].
  • Confirmation came from chromatin immunoprecipitation (ChIP) assays demonstrating that all components of this complex, including Leo1, cross-linked to the promoter, coding region, and 3' end of the ADH1 gene [3].
  • The gene LEO1 on yeast chromosome XV encodes a non-essential, extremely hydrophilic protein [4].
  • We show the gene organization of the entire region and report the nucleotide sequence of the gene, LEO1, which occurs in single copy in the haploid genome [4].


  1. The Paf1 complex physically and functionally associates with transcription elongation factors in vivo. Squazzo, S.L., Costa, P.J., Lindstrom, D.L., Kumer, K.E., Simic, R., Jennings, J.L., Link, A.J., Arndt, K.M., Hartzog, G.A. EMBO J. (2002) [Pubmed]
  2. Ctr9, Rtf1, and Leo1 are components of the Paf1/RNA polymerase II complex. Mueller, C.L., Jaehning, J.A. Mol. Cell. Biol. (2002) [Pubmed]
  3. RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach. Krogan, N.J., Kim, M., Ahn, S.H., Zhong, G., Kobor, M.S., Cagney, G., Emili, A., Shilatifard, A., Buratowski, S., Greenblatt, J.F. Mol. Cell. Biol. (2002) [Pubmed]
  4. The gene LEO1 on yeast chromosome XV encodes a non-essential, extremely hydrophilic protein. Magdolen, V., Lang, P., Mages, G., Hermann, H., Bandlow, W. Biochim. Biophys. Acta (1994) [Pubmed]
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