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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

HEM15  -  Hem15p

Saccharomyces cerevisiae S288c

 
 
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High impact information on HEM15

  • Northern (RNA) analysis showed a slight (1.5-2-fold) repression of HEM15 expression by glucose [1].
  • Sequence analysis of a 2.9-kilobase genomic DNA fragment revealed an open reading frame of 1179 nucleotides, plus a gene coding for a tRNA(Val)(GUU) and delta elements downstream from the 3'-end of HEM15 [1].
  • The HEM15 gene in Saccharomyces cerevisiae encodes ferrochelatase (EC 4.99.1.1, protoheme ferrolyase), a mitochondrial inner membrane-bound enzyme which catalyzes the insertion of ferrous ion into protoporphyrin IX, the last step in protoheme biosynthesis [1].
  • These genes were expressed in a Saccharomyces cerevisiae mutant in which the endogenous ferrochelatase gene (HEM15) had been deleted, and the phenotypes of the transformants were characterized [2].
  • Ferrochelatase (protoheme ferro-lyase, EC 4.99.1.1) has been studied in yeast mitochondrial membranes with special reference to zinc-chelatase and iron-chelatase activities [3].

References

  1. The ferrochelatase from Saccharomyces cerevisiae. Sequence, disruption, and expression of its structural gene HEM15. Labbe-Bois, R. J. Biol. Chem. (1990) [Pubmed]
  2. Activity and cellular location in Saccharomyces cerevisiae of chimeric mouse/yeast and Bacillus subtilis/yeast ferrochelatases. Góra, M., Rytka, J., Labbe-Bois, R. Arch. Biochem. Biophys. (1999) [Pubmed]
  3. Kinetic studies of ferrochelatase in yeast. Zinc or iron as competing substrates. Camadro, J.M., Labbe, P. Biochim. Biophys. Acta (1982) [Pubmed]
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