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Gene Review

HEM15  -  Hem15p

Saccharomyces cerevisiae S288c

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High impact information on HEM15

  • Northern (RNA) analysis showed a slight (1.5-2-fold) repression of HEM15 expression by glucose [1].
  • Sequence analysis of a 2.9-kilobase genomic DNA fragment revealed an open reading frame of 1179 nucleotides, plus a gene coding for a tRNA(Val)(GUU) and delta elements downstream from the 3'-end of HEM15 [1].
  • The HEM15 gene in Saccharomyces cerevisiae encodes ferrochelatase (EC, protoheme ferrolyase), a mitochondrial inner membrane-bound enzyme which catalyzes the insertion of ferrous ion into protoporphyrin IX, the last step in protoheme biosynthesis [1].
  • These genes were expressed in a Saccharomyces cerevisiae mutant in which the endogenous ferrochelatase gene (HEM15) had been deleted, and the phenotypes of the transformants were characterized [2].
  • Ferrochelatase (protoheme ferro-lyase, EC has been studied in yeast mitochondrial membranes with special reference to zinc-chelatase and iron-chelatase activities [3].


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