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Gene Review:

FeCH - Ferrochelatase

Drosophila melanogaster

Synonyms: CG2098, Dmel\CG2098, FeCh, Ferrochelatase, mitochondrial, Heme synthase, ...

Sellers, V.M. et al., Wang, K.F. et al.

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High impact information on ferrochelatase

Evidence that the fourth ligand to the [2Fe-2S] cluster in animal ferrochelatase is a cysteine. Characterization of the enzyme from Drosophila melanogaster [1].
Cysteine at position 196 in human recombinant ferrochelatase when changed to a serine results in an inactive enzyme that is lacking the [2Fe-2S] cluster [1].

Analytical, diagnostic and therapeutic context of ferrochelatase

Purification, crystallization and preliminary X-ray analysis of Drosophila melanogaster ferrochelatase [2].

References

Evidence that the fourth ligand to the [2Fe-2S] cluster in animal ferrochelatase is a cysteine. Characterization of the enzyme from Drosophila melanogaster. Sellers, V.M., Wang, K.F., Johnson, M.K., Dailey, H.A. J. Biol. Chem. (1998) [Pubmed]
Purification, crystallization and preliminary X-ray analysis of Drosophila melanogaster ferrochelatase. Wang, K.F., Wu, C.K., Sellers, V.M., Rose, J.P., Wang, B.C., Dailey, H.A. Acta Crystallogr. D Biol. Crystallogr. (1999) [Pubmed]

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AgaP_AGAP003719	Anopheles gambiae str. PEST
FC2	Arabidopsis thaliana
AGOS_AGR272W	Ashbya gossypii ATCC 10895
FECH	Bos taurus
FECH	Canis lupus familiaris
fech	Danio rerio
FECH	Gallus gallus
FECH	Homo sapiens
KLLA0F20141g	Kluyveromyces lactis NRRL Y-1140
FECH	Macaca mulatta
MGG_15723	Magnaporthe oryzae 70-15
Fech	Mus musculus
NCU08291	Neurospora crassa OR74A
Os05g0361200	Oryza sativa Japonica Group
FECH	Pan troglodytes
Fech	Rattus norvegicus
HEM15	Saccharomyces cerevisiae S288c
hem15	Schizosaccharomyces pombe 972h-
fech	Xenopus (Silurana) tropicalis

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