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Gene Review:

NDD1 - Ndd1p

Saccharomyces cerevisiae S288c

Synonyms: Nuclear division defective protein 1, YOR372C

Loy, C.J. et al., Reynolds, D. et al.

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High impact information on NDD1

Although an essential gene, NDD1 is dispensable in cells expressing a truncated form of Fkh2p lacking its C terminus [1].
Instead, overexpression of NDD1 prevents the formation of one of the complexes whose appearance correlates with the termination of CLB2 expression in G1 [2].
Both CLB2 expression and its upregulation by NDD1 are mediated by a 240-bp promoter sequence that contains four MCM1-binding sites [2].
We show that overexpression of Ndd1 results in the upregulation of both CLB1 and CLB2 transcription, suggesting that the suppression of cdc28-1N by NDD1 may be due to an accumulation of these cyclins [2].
We have isolated a gene, NDD1, which at a high dosage suppresses the nuclear-division defect of cdc28-1N [2].

Biological context of NDD1

Its expression during the cell cycle is tightly regulated such that NDD1 RNA is most abundant during the S phase [2].

References

Recruitment of Thr 319-phosphorylated Ndd1p to the FHA domain of Fkh2p requires Clb kinase activity: a mechanism for CLB cluster gene activation. Reynolds, D., Shi, B.J., McLean, C., Katsis, F., Kemp, B., Dalton, S. Genes Dev. (2003) [Pubmed]
NDD1, a high-dosage suppressor of cdc28-1N, is essential for expression of a subset of late-S-phase-specific genes in Saccharomyces cerevisiae. Loy, C.J., Lydall, D., Surana, U. Mol. Cell. Biol. (1999) [Pubmed]

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