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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Cell Nucleus Division

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Disease relevance of Cell Nucleus Division


High impact information on Cell Nucleus Division


Biological context of Cell Nucleus Division


Anatomical context of Cell Nucleus Division


Associations of Cell Nucleus Division with chemical compounds


Gene context of Cell Nucleus Division

  • SMC1: an essential yeast gene encoding a putative head-rod-tail protein is required for nuclear division and defines a new ubiquitous protein family [24].
  • Dual functions of CDC6: a yeast protein required for DNA replication also inhibits nuclear division [25].
  • We propose a model in which the Elm1 kinase functions in a mitotic signaling network that controls events required for normal bud growth and cytokinesis, while the Swe1 kinase functions in a checkpoint pathway that delays nuclear division in response to defects in these events [26].
  • We have isolated a gene, NDD1, which at a high dosage suppresses the nuclear-division defect of cdc28-1N [27].
  • We have isolated three mutant alleles of CDC4 (cdc4-10, cdc4-11, and cdc4-16) which suppress the nuclear division defect of cdc20-1 cells [28].

Analytical, diagnostic and therapeutic context of Cell Nucleus Division


  1. Differential response to cytochalasin B among cells transformed by DNA and RNA tumor viruses. O'Neill, F.J., Miller, T.H., Hoen, J., Stradley, B., Devlahovich, V. J. Natl. Cancer Inst. (1975) [Pubmed]
  2. Hypoxia and nitric oxide induce a rapid, reversible cell cycle arrest of the Drosophila syncytial divisions. DiGregorio, P.J., Ubersax, J.A., O'Farrell, P.H. J. Biol. Chem. (2001) [Pubmed]
  3. Degree of enhancement of polyamine biosynthetic decarboxylase activities in human tumors: a useful new index of degree of malignancy. Scalabrino, G., Ferioli, M.E. Cancer Detect. Prev. (1985) [Pubmed]
  4. A mechanism for coupling exit from mitosis to partitioning of the nucleus. Bardin, A.J., Visintin, R., Amon, A. Cell (2000) [Pubmed]
  5. Identification of asymmetrically localized determinant, Ash1p, required for lineage-specific transcription of the yeast HO gene. Sil, A., Herskowitz, I. Cell (1996) [Pubmed]
  6. Gamma-tubulin is present in Drosophila melanogaster and Homo sapiens and is associated with the centrosome. Zheng, Y., Jung, M.K., Oakley, B.R. Cell (1991) [Pubmed]
  7. Mutation of a gene that encodes a kinesin-like protein blocks nuclear division in A. nidulans. Enos, A.P., Morris, N.R. Cell (1990) [Pubmed]
  8. The engrailed locus of D. melanogaster provides an essential zygotic function in precellular embryos. Karr, T.L., Ali, Z., Drees, B., Kornberg, T. Cell (1985) [Pubmed]
  9. Disruption of the Dictyostelium myosin heavy chain gene by homologous recombination. De Lozanne, A., Spudich, J.A. Science (1987) [Pubmed]
  10. Tousled-like kinase functions with the chromatin assembly pathway regulating nuclear divisions. Carrera, P., Moshkin, Y.M., Gronke, S., Sillje, H.H., Nigg, E.A., Jackle, H., Karch, F. Genes Dev. (2003) [Pubmed]
  11. Negative regulation of FAR1 at the Start of the yeast cell cycle. McKinney, J.D., Chang, F., Heintz, N., Cross, F.R. Genes Dev. (1993) [Pubmed]
  12. Cell-cycle checkpoints that ensure coordination between nuclear and cytoplasmic events in Saccharomyces cerevisiae. Lew, D.J. Curr. Opin. Genet. Dev. (2000) [Pubmed]
  13. The Dbf2 and Dbf20 protein kinases of budding yeast are activated after the metaphase to anaphase cell cycle transition. Toyn, J.H., Johnston, L.H. EMBO J. (1994) [Pubmed]
  14. PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis. Jiang, W., Jimenez, G., Wells, N.J., Hope, T.J., Wahl, G.M., Hunter, T., Fukunaga, R. Mol. Cell (1998) [Pubmed]
  15. Maternal effect mutations of the sponge locus affect actin cytoskeletal rearrangements in Drosophila melanogaster embryos. Postner, M.A., Miller, K.G., Wieschaus, E.F. J. Cell Biol. (1992) [Pubmed]
  16. Selective destruction of cultured tumor cells with uncontrolled nuclear division by cytochalasin B and cytosine arabinoside. O'Neill, F.J. Cancer Res. (1975) [Pubmed]
  17. In vitro growth control phenotypes of transformed rodent cells prior to and following tumorigenesis. O'Neill, F.J., Renzetti, L. Cancer Res. (1983) [Pubmed]
  18. Most of centrin in animal cells is not centrosome-associated and centrosomal centrin is confined to the distal lumen of centrioles. Paoletti, A., Moudjou, M., Paintrand, M., Salisbury, J.L., Bornens, M. J. Cell. Sci. (1996) [Pubmed]
  19. Diverse essential functions revealed by complementing yeast calmodulin mutants. Ohya, Y., Botstein, D. Science (1994) [Pubmed]
  20. A novel suppressor of ras1 in fission yeast, byr4, is a dosage-dependent inhibitor of cytokinesis. Song, K., Mach, K.E., Chen, C.Y., Reynolds, T., Albright, C.F. J. Cell Biol. (1996) [Pubmed]
  21. Cdc28 tyrosine phosphorylation and the morphogenesis checkpoint in budding yeast. Sia, R.A., Herald, H.A., Lew, D.J. Mol. Biol. Cell (1996) [Pubmed]
  22. Timing of nuclear division cycle in Neurospora crassa. Martegani, E., Tomè, F., Trezzi, F. J. Cell. Sci. (1981) [Pubmed]
  23. Carbon dioxide evolution during the cell cycle of the fission yeast Schizosaccharomyces pombe. Creanor, J. J. Cell. Sci. (1978) [Pubmed]
  24. SMC1: an essential yeast gene encoding a putative head-rod-tail protein is required for nuclear division and defines a new ubiquitous protein family. Strunnikov, A.V., Larionov, V.L., Koshland, D. J. Cell Biol. (1993) [Pubmed]
  25. Dual functions of CDC6: a yeast protein required for DNA replication also inhibits nuclear division. Bueno, A., Russell, P. EMBO J. (1992) [Pubmed]
  26. The elm1 kinase functions in a mitotic signaling network in budding yeast. Sreenivasan, A., Kellogg, D. Mol. Cell. Biol. (1999) [Pubmed]
  27. NDD1, a high-dosage suppressor of cdc28-1N, is essential for expression of a subset of late-S-phase-specific genes in Saccharomyces cerevisiae. Loy, C.J., Lydall, D., Surana, U. Mol. Cell. Biol. (1999) [Pubmed]
  28. Cdc4, a protein required for the onset of S phase, serves an essential function during G(2)/M transition in Saccharomyces cerevisiae. Goh, P.Y., Surana, U. Mol. Cell. Biol. (1999) [Pubmed]
  29. The Cdc42p GTPase is involved in a G2/M morphogenetic checkpoint regulating the apical-isotropic switch and nuclear division in yeast. Richman, T.J., Sawyer, M.M., Johnson, D.I. J. Biol. Chem. (1999) [Pubmed]
  30. Nuclear envelope fission is linked to cytokinesis in budding yeast. Lippincott, J., Li, R. Exp. Cell Res. (2000) [Pubmed]
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