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Gene Review

MLP2  -  Mlp2p

Saccharomyces cerevisiae S288c

Synonyms: Myosin-like protein 2, Protein MLP2, YIL149C
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High impact information on MLP2

  • Furthermore, double deletion of MLP1 and MLP2 disrupts the clustering of perinuclear telomeres and releases telomeric gene repression [1].
  • Mlp2 physically tethers Yku70 to the nuclear periphery, thus forming a link between chromatin and the nuclear envelope [1].
  • Surprisingly, factors involved in microtubule-mediated intracellular movement (Tub3, Dhc1, and Mlp2) appear to play no appreciable role in homolog juxtaposition, unlike their counterparts in fission yeast [2].

Biological context of MLP2

  • Remarkably, cells harboring a double deletion of MLP1 and MLP2 were viable, although they showed a slower net rate of active nuclear import and faster passive efflux of a reporter protein [3].

Anatomical context of MLP2

  • Here we show that nuclear-pore-complex extensions formed by the conserved TPR homologues Mlp1 and Mlp2 are responsible for the structural and functional organization of perinuclear chromatin [1].


  1. Nuclear pore complexes in the organization of silent telomeric chromatin. Galy, V., Olivo-Marin, J.C., Scherthan, H., Doye, V., Rascalou, N., Nehrbass, U. Nature (2000) [Pubmed]
  2. Analysis of close stable homolog juxtaposition during meiosis in mutants of Saccharomyces cerevisiae. Lui, D.Y., Peoples-Holst, T.L., Mell, J.C., Wu, H.Y., Dean, E.W., Burgess, S.M. Genetics (2006) [Pubmed]
  3. Proteins connecting the nuclear pore complex with the nuclear interior. Strambio-de-Castillia, C., Blobel, G., Rout, M.P. J. Cell Biol. (1999) [Pubmed]
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