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LYS12  -  homoisocitrate dehydrogenase

Saccharomyces cerevisiae S288c

Synonyms: HIcDH, Homoisocitrate dehydrogenase, mitochondrial, LYS10, LYS11, YI9910.02C, ...
 
 
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High impact information on LYS12

  • The identification of enzymes mediating site-specific acetylation of H4 at Lys5 and Lys12 may help explain the function of the acetylation of newly synthesized histones [1].
  • Cleavage was established at Lys5 and His19 of histatin 5, Lys11, Arg12, Phe14, Glu16, Lys17, His18 and Ser20 of dh-5 and Ala4 and Lys11 of P-113 [2].
  • Lys10 mutants displayed NAD-reducing activity, whereas lys9 mutants retained some carboxylating activity [3].

References

  1. Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase. Verreault, A., Kaufman, P.D., Kobayashi, R., Stillman, B. Curr. Biol. (1998) [Pubmed]
  2. Internalisation and degradation of histatin 5 by Candida albicans. Ruissen, A.L., Groenink, J., Krijtenberg, P., Walgreen-Weterings, E., van 't Hof, W., Veerman, E.C., Nieuw Amerongen, A.V. Biol. Chem. (2003) [Pubmed]
  3. Wild-type and mutant forms of homoisocitric dehydrogenase in the yeast Saccharomycopsis lipolytica. Gaillardin, C.M., Ribet, A.M., Heslot, H. Eur. J. Biochem. (1982) [Pubmed]
 
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