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Chemical Compound Review

Saralasin acetate     (2S)-2-[[1-[(2S)-2-[[(2S)-2- [[(2S)-2...

Synonyms: Sarenin, AC1NUZ3M, 39698-78-7, UNII-FO21Z580M4, 34273-10-4 (Parent)
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Disease relevance of

 

High impact information on

 

Biological context of

 

Anatomical context of

  • Among the 189 "P-113 nonresponders," peripheral PRA was elevated in seven (3.8%), and renal vein PRA ratio was abnormal in two patients, who might represent exceptions to the otherwise successful record of the P-113 response in identifying "angiotensinoginic" hypertensives [3].
  • To examine the role of the renin-angiotensin system in aldosterone regulation, P-113 ([Sar1,Ala8]angiotensin II) was infused into the arterial blood supply of the transplanted adrenal gland in conscious sheep [12].
 

Associations of with other chemical compounds

 

Gene context of

  • Cleavage was established at Lys5 and His19 of histatin 5, Lys11, Arg12, Phe14, Glu16, Lys17, His18 and Ser20 of dh-5 and Ala4 and Lys11 of P-113 [15].
  • For the intent-to-treat population, significantly smaller %BOP changes were noted in subjects treated with 0.0625, 0.125 and 0.375% P-113 gels (17.4, 18.18 and 17.9%, respectively) versus placebo (28.0%) (p < 0.05) at day 29 [16].
  • 3. Intravenous infusion of inhibitor P-113, 5.5 nmol min-1 kg-1, into anaesthetized rats produced highly significant increases in PRA and plasma renin concentration without reduction in arterial pressure [13].
  • These experiments indicate that during RAO release of renin causes, through formation of angiotensin, an increase in RVR in the contralateral kidney and intra-arterial administration of P-113 restores the vascular resistance to a near-normal level [11].
 

Analytical, diagnostic and therapeutic context of

References

  1. Use of an angiotensin II antagonist (saralasin) in the recognition of "angiotensinogenic" hypertension;. Streeten, D.H., Anderson, G.H., Freiberg, J.M., Dalakos, T.G. N. Engl. J. Med. (1975) [Pubmed]
  2. Mechanisms involved in two-kidney renal hypertension induced by constriction of one renal artery. Freeman, R.H., Davis, J.O., Watkins, B.E., Lohmeier, T.E. Circ. Res. (1977) [Pubmed]
  3. Identification of angiotensinogenic hypertension in man using 1-sar-8-ala-angiotensin II (Saralasin, P-113). Streeten, D.H., Freiberg, J.M., Anderson, G.H., Dalakos, T.G. Circ. Res. (1975) [Pubmed]
  4. Anticandida activity is retained in P-113, a 12-amino-acid fragment of histatin 5. Rothstein, D.M., Spacciapoli, P., Tran, L.T., Xu, T., Roberts, F.D., Dalla Serra, M., Buxton, D.K., Oppenheim, F.G., Friden, P. Antimicrob. Agents Chemother. (2001) [Pubmed]
  5. Clinical and microbial evaluation of a histatin-containing mouthrinse in humans with experimental gingivitis. Mickels, N., McManus, C., Massaro, J., Friden, P., Braman, V., D'Agostino, R., Oppenheim, F., Warbington, M., Dibart, S., Van Dyke, T. Journal of clinical periodontology. (2001) [Pubmed]
  6. Effect of intrarenal angiotensin II blockade on renal function in conscious dogs. Kimbrough, H.M., Vaughan, E.D., Carey, R.M., Ayers, C.R. Circ. Res. (1977) [Pubmed]
  7. In vitro activity of the histatin derivative P-113 against multidrug-resistant pathogens responsible for pneumonia in immunocompromised patients. Giacometti, A., Cirioni, O., Kamysz, W., D'Amato, G., Silvestri, C., Del Prete, M.S., Licci, A., Riva, A., Lukasiak, J., Scalise, G. Antimicrob. Agents Chemother. (2005) [Pubmed]
  8. P-113D, an antimicrobial peptide active against Pseudomonas aeruginosa, retains activity in the presence of sputum from cystic fibrosis patients. Sajjan, U.S., Tran, L.T., Sole, N., Rovaldi, C., Akiyama, A., Friden, P.M., Forstner, J.F., Rothstein, D.M. Antimicrob. Agents Chemother. (2001) [Pubmed]
  9. Diagnosis of angiotensinogenic hypertension: the complementary roles of renal scintigraphy and the saralasin infusion test. McAfee, J.G., Thomas, F.D., Grossman, Z., Streeten, D.H., Dailey, E., Gagne, G. J. Nucl. Med. (1977) [Pubmed]
  10. Candida glabrata is unusual with respect to its resistance to cationic antifungal proteins. Helmerhorst, E.J., Venuleo, C., Beri, A., Oppenheim, F.G. Yeast (2005) [Pubmed]
  11. Effect of [Sar1, Ala8]angiotensin II on renal vascular resistance. Satoh, S., Zimmerman, B.G. Am. J. Physiol. (1975) [Pubmed]
  12. Effect of adrenal arterial infusion of P-113 on aldosterone secretion in Na-deficient sheep. Blair-West, J.R., Coghlan, J.P., Denton, D.A., Hardy, K.J., Scoggins, B.A., Wright, R.D. Am. J. Physiol. (1979) [Pubmed]
  13. Angiotensin blockade in studies of the feedback control of renin release in rats and rabbits. Stokes, G.S., Oates, H.F., Weber, M.A. Clinical science and molecular medicine. Supplement. (1975) [Pubmed]
  14. Screening of angiotensin II dependent hypertensive patients using a linear classifier. Koivo, A.J. Medical informatics = Médecine et informatique. (1981) [Pubmed]
  15. Internalisation and degradation of histatin 5 by Candida albicans. Ruissen, A.L., Groenink, J., Krijtenberg, P., Walgreen-Weterings, E., van 't Hof, W., Veerman, E.C., Nieuw Amerongen, A.V. Biol. Chem. (2003) [Pubmed]
  16. Safety and clinical effects of topical histatin gels in humans with experimental gingivitis. Paquette, D.W., Simpson, D.M., Friden, P., Braman, V., Williams, R.C. Journal of clinical periodontology. (2002) [Pubmed]
  17. The intrinsic brain iso-renin--angiotensin system in the rat: its possible role in central mechanisms of blood pressure regulation. Ganten, D., Hutchinson, J.S., Schelling, P. Clinical science and molecular medicine. Supplement. (1975) [Pubmed]
  18. Histatin-derived peptides: potential agents to treat localised infections. Rothstein, D.M., Helmerhorst, E.J., Spacciapoli, P., Oppenheim, F.G., Friden, P. Expert opinion on emerging drugs. (2002) [Pubmed]
 
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