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Gene Review

LYS9  -  saccharopine dehydrogenase (NADP+, L...

Saccharomyces cerevisiae S288c

Synonyms: LYS13, N3461, Saccharopine reductase, YNR050C
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High impact information on LYS9

  • Here we show that trimethylated H3 Lys9, but not dimethylated H3 Lys9, marks chromatin regions for cytosine methylation and that DIM-5 specifically creates this mark [1].
  • The predicted polypeptide has an N-terminal LKR domain and a C-terminal SDH domain that are similar to the yeast LYS1 and LYS9 monofunctional proteins, respectively [2].
  • These cells carry elevated levels of methylated histone H3-Lys4 and reduced levels of methylated histone H3-Lys9 [3].
  • We mapped pop2 to chromosome XIV, distal to lys9 and SUP28, indicating that POP2 is a newly-identified locus [4].
  • This identity extends to the high-energy conformations of the active-site residues Lys13 and Ser211, as well as the positions of several bound water molecules that are retained in the active site when PGH is bound [5].

Biological context of LYS9


Associations of LYS9 with chemical compounds


Other interactions of LYS9


  1. Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa. Tamaru, H., Zhang, X., McMillen, D., Singh, P.B., Nakayama, J., Grewal, S.I., Allis, C.D., Cheng, X., Selker, E.U. Nat. Genet. (2003) [Pubmed]
  2. The role of opaque2 in the control of lysine-degrading activities in developing maize endosperm. Kemper, E.L., Neto, G.C., Papes, F., Moraes, K.C., Leite, A., Arruda, P. Plant Cell (1999) [Pubmed]
  3. CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex. Lee, J.H., Skalnik, D.G. J. Biol. Chem. (2005) [Pubmed]
  4. Molecular analysis of POP2 gene, a gene required for glucose-derepression of gene expression in Saccharomyces cerevisiae. Sakai, A., Chibazakura, T., Shimizu, Y., Hishinuma, F. Nucleic Acids Res. (1992) [Pubmed]
  5. Crystal structure of recombinant chicken triosephosphate isomerase-phosphoglycolohydroxamate complex at 1.8-A resolution. Zhang, Z., Sugio, S., Komives, E.A., Liu, K.D., Knowles, J.R., Petsko, G.A., Ringe, D. Biochemistry (1994) [Pubmed]
  6. Biosynthetic and regulatory role of lys9 mutants of Saccharomyces cerevisiae. Winston, M.K., Bhattacharjee, J.K. Curr. Genet. (1987) [Pubmed]
  7. Novel chimeric spermidine synthase-saccharopine dehydrogenase gene (SPE3-LYS9) in the human pathogen Cryptococcus neoformans. Kingsbury, J.M., Yang, Z., Ganous, T.M., Cox, G.M., McCusker, J.H. Eukaryotic Cell (2004) [Pubmed]
  8. Control of enzyme synthesis in the lysine biosynthetic pathway of Saccharomyces cerevisiae. Evidence for a regulatory role of gene LYS14. Ramos, F., Dubois, E., Piérard, A. Eur. J. Biochem. (1988) [Pubmed]
  9. Two unlinked lysine genes (LYS9 and LYS14) are required for the synthesis of saccharopine reductase in Saccharomyces cerevisiae. Borell, C.W., Urrestarazu, L.A., Bhattacharjee, J.K. J. Bacteriol. (1984) [Pubmed]
  10. Wild-type and mutant forms of homoisocitric dehydrogenase in the yeast Saccharomycopsis lipolytica. Gaillardin, C.M., Ribet, A.M., Heslot, H. Eur. J. Biochem. (1982) [Pubmed]
  11. Conversion of pipecolic acid into lysine in Penicillium chrysogenum requires pipecolate oxidase and saccharopine reductase: characterization of the lys7 gene encoding saccharopine reductase. Naranjo, L., Martin de Valmaseda, E., Bañuelos, O., Lopez, P., Riaño, J., Casqueiro, J., Martin, J.F. J. Bacteriol. (2001) [Pubmed]
  12. Molecular cloning and genetic mapping of the PET494 gene of Saccharomyces cerevisiae. Müller, P.P., Fox, T.D. Mol. Gen. Genet. (1984) [Pubmed]
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