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Gene Review:

SDS3 - Sds3p

Saccharomyces cerevisiae S288c

Synonyms: Suppressor of defective silencing protein 3, Transcriptional regulatory protein SDS3, YIL084C

Lechner, T. et al., Dorland, S. et al., Vannier, D. et al., Vannier, D. et al.

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High impact information on SDS3

SDS3 (suppressor of defective silencing 3) was originally identified in a screen for mutations that cause increased silencing of a crippled HMR silencer in a rap1 mutant background [1].
In addition, sds3 mutants have phenotypes very similar to those seen in sin3 and rpd3 mutants, suggesting that it functions in the same genetic pathway [1].
Significantly, growth in the presence of 1 M sorbitol or overexpression of PKC1 also partially suppresses the lethal phenotype of the sds3 swi6 strain [2].

Biological context of SDS3

The remaining gene from this screen described in this report is SDS3, previously identified in a screen for mutations that increase silencing at HML, HMR, and telomere-linked genes, a phenotype also seen in sin3 and rpd3 mutants [3].

Other interactions of SDS3

Evidence that the transcriptional regulators SIN3 and RPD3, and a novel gene (SDS3) with similar functions, are involved in transcriptional silencing in S. cerevisiae [4].

References

Sds3 (suppressor of defective silencing 3) is an integral component of the yeast Sin3[middle dot]Rpd3 histone deacetylase complex and is required for histone deacetylase activity. Lechner, T., Carrozza, M.J., Yu, Y., Grant, P.A., Eberharter, A., Vannier, D., Brosch, G., Stillman, D.J., Shore, D., Workman, J.L. J. Biol. Chem. (2000) [Pubmed]
A role for Sds3p, a component of the Rpd3p/Sin3p deacetylase complex, in maintaining cellular integrity in Saccharomyces cerevisiae. Vannier, D., Damay, P., Shore, D. Mol. Genet. Genomics (2001) [Pubmed]
Roles for the Saccharomyces cerevisiae SDS3, CBK1 and HYM1 genes in transcriptional repression by SIN3. Dorland, S., Deegenaars, M.L., Stillman, D.J. Genetics (2000) [Pubmed]
Evidence that the transcriptional regulators SIN3 and RPD3, and a novel gene (SDS3) with similar functions, are involved in transcriptional silencing in S. cerevisiae. Vannier, D., Balderes, D., Shore, D. Genetics (1996) [Pubmed]

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AGOS_ADL200C	Ashbya gossypii ATCC 10895
KLLA0E08691g	Kluyveromyces lactis NRRL Y-1140

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