Gene Review:
SIN3 - Sin3p
Saccharomyces cerevisiae S288c
Synonyms:
CPE1, GAM2, RPD1, SDI1, SDS16, ...
- The Isw2 chromatin remodeling complex represses early meiotic genes upon recruitment by Ume6p. Goldmark, J.P., Fazzio, T.G., Estep, P.W., Church, G.M., Tsukiyama, T. Cell (2000)
- Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters. Kadosh, D., Struhl, K. Cell (1997)
- Cell cycle-regulated histone acetylation required for expression of the yeast HO gene. Krebs, J.E., Kuo, M.H., Allis, C.D., Peterson, C.L. Genes Dev. (1999)
- SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Zhang, Y., Sun, Z.W., Iratni, R., Erdjument-Bromage, H., Tempst, P., Hampsey, M., Reinberg, D. Mol. Cell (1998)
- TIS7 interacts with the mammalian SIN3 histone deacetylase complex in epithelial cells. Vietor, I., Vadivelu, S.K., Wick, N., Hoffman, R., Cotten, M., Seiser, C., Fialka, I., Wunderlich, W., Haase, A., Korinkova, G., Brosch, G., Huber, L.A. EMBO J. (2002)
- The Saccharomyces cerevisiae SIN3 gene, a negative regulator of HO, contains four paired amphipathic helix motifs. Wang, H., Clark, I., Nicholson, P.R., Herskowitz, I., Stillman, D.J. Mol. Cell. Biol. (1990)
- Architectural transcription factors and the SAGA complex function in parallel pathways to activate transcription. Yu, Y., Eriksson, P., Stillman, D.J. Mol. Cell. Biol. (2000)
- Combinatorial regulation of phospholipid biosynthetic gene expression by the UME6, SIN3 and RPD3 genes. Elkhaimi, M., Kaadige, M.R., Kamath, D., Jackson, J.C., Biliran, H., Lopes, J.M. Nucleic Acids Res. (2000)
- Sds3 (suppressor of defective silencing 3) is an integral component of the yeast Sin3[middle dot]Rpd3 histone deacetylase complex and is required for histone deacetylase activity. Lechner, T., Carrozza, M.J., Yu, Y., Grant, P.A., Eberharter, A., Vannier, D., Brosch, G., Stillman, D.J., Shore, D., Workman, J.L. J. Biol. Chem. (2000)
- Roles for the Saccharomyces cerevisiae SDS3, CBK1 and HYM1 genes in transcriptional repression by SIN3. Dorland, S., Deegenaars, M.L., Stillman, D.J. Genetics (2000)
- Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein. Dhordain, P., Albagli, O., Lin, R.J., Ansieau, S., Quief, S., Leutz, A., Kerckaert, J.P., Evans, R.M., Leprince, D. Proc. Natl. Acad. Sci. U.S.A. (1997)
- RPD1 (SIN3/UME4) is required for maximal activation and repression of diverse yeast genes. Vidal, M., Strich, R., Esposito, R.E., Gaber, R.F. Mol. Cell. Biol. (1991)
- Identification of a Saccharomyces cerevisiae DNA-binding protein involved in transcriptional regulation. Wang, H., Nicholson, P.R., Stillman, D.J. Mol. Cell. Biol. (1990)
- Coupling of Saccharomyces cerevisiae early meiotic gene expression to DNA replication depends upon RPD3 and SIN3. Lamb, T.M., Mitchell, A.P. Genetics (2001)
- Saccharomyces cerevisiae Sin3p facilitates DNA double-strand break repair. Jazayeri, A., McAinsh, A.D., Jackson, S.P. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Identification of the Sin3-binding site in Ume6 defines a two-step process for conversion of Ume6 from a transcriptional repressor to an activator in yeast. Washburn, B.K., Esposito, R.E. Mol. Cell. Biol. (2001)
- SIN3-dependent transcriptional repression by interaction with the Mad1 DNA-binding protein. Kasten, M.M., Ayer, D.E., Stillman, D.J. Mol. Cell. Biol. (1996)
- Genomewide studies of histone deacetylase function in yeast. Bernstein, B.E., Tong, J.K., Schreiber, S.L. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase. Arévalo-Rodríguez, M., Cardenas, M.E., Wu, X., Hanes, S.D., Heitman, J. EMBO J. (2000)
- SIN3 works through two different promoter elements to regulate INO1 gene expression in yeast. Slekar, K.H., Henry, S.A. Nucleic Acids Res. (1995)
- Opi1p, Ume6p and Sin3p control expression from the promoter of the INO2 regulatory gene via a novel regulatory cascade. Kaadige, M.R., Lopes, J.M. Mol. Microbiol. (2003)
- Regulation of the yeast INO1 gene. The products of the INO2, INO4 and OPI1 regulatory genes are not required for repression in response to inositol. Graves, J.A., Henry, S.A. Genetics (2000)
- Genetic interactions between SIN3 mutations and the Saccharomyces cerevisiae transcriptional activators encoded by MCM1, STE12, and SWI1. Wang, H., Reynolds-Hager, L., Stillman, D.J. Mol. Gen. Genet. (1994)
- The yeast SIN3 gene product negatively regulates the activity of the human progesterone receptor and positively regulates the activities of GAL4 and the HAP1 activator. Nawaz, Z., Baniahmad, C., Burris, T.P., Stillman, D.J., O'Malley, B.W., Tsai, M.J. Mol. Gen. Genet. (1994)
- A large protein complex containing the yeast Sin3p and Rpd3p transcriptional regulators. Kasten, M.M., Dorland, S., Stillman, D.J. Mol. Cell. Biol. (1997)
- The yeast potassium transporter TRK2 is able to substitute for TRK1 in its biological function under low K and low pH conditions. Michel, B., Lozano, C., Rodríguez, M., Coria, R., Ramírez, J., Peña, A. Yeast (2006)