Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

SNP1 - Snp1p

Saccharomyces cerevisiae S288c

Synonyms: U1 70K, U1 small nuclear ribonucleoprotein 70 kDa homolog, U1 small nuclear ribonucleoprotein SNP1, U1 snRNP 70 kDa homolog, U1 snRNP protein SNP1, ...

Hilleren, P.J. et al., Smith, V. et al., Awasthi, S. et al., Kao, H.Y. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SNP1

To address this question, we have expressed the SNP1 gene as a fusion protein in E. coli and developed a gel shift assay for U1 RNA binding [1].

High impact information on SNP1

The complete human 70K gene did not complement snp1, but the lethal snp1 mutation was rescued by plasmids bearing a chimera in which over half the yeast gene was replaced with the homologous region of the human 70K gene, including the RNA-binding domain [2].
The Saccharomyces cerevisiae SNP1 gene encodes a protein that shares 30% amino acid identity with the mammalian U1 small nuclear ribonucleoprotein particle protein 70K (U1-70K) [3].
We have tested deletion alleles of SNP1 for their ability to complement these phenotypes [3].
New roles for the Snp1 and Exo84 proteins in yeast pre-mRNA splicing [4].

Anatomical context of SNP1

This interaction suggests some novel functions for Snp1p and the U1 small nuclear ribonucleoprotein late in spliceosome development [4].

References

The yeast homolog of the U1 snRNP protein 70K is encoded by the SNP1 gene. Kao, H.Y., Siliciano, P.G. Nucleic Acids Res. (1992) [Pubmed]
Cloning of a yeast U1 snRNP 70K protein homologue: functional conservation of an RNA-binding domain between humans and yeast. Smith, V., Barrell, B.G. EMBO J. (1991) [Pubmed]
The amino-terminal domain of yeast U1-70K is necessary and sufficient for function. Hilleren, P.J., Kao, H.Y., Siliciano, P.G. Mol. Cell. Biol. (1995) [Pubmed]
New roles for the Snp1 and Exo84 proteins in yeast pre-mRNA splicing. Awasthi, S., Palmer, R., Castro, M., Mobarak, C.D., Ruby, S.W. J. Biol. Chem. (2001) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AGOS_ADL063W	Ashbya gossypii ATCC 10895
KLLA0C08019g	Kluyveromyces lactis NRRL Y-1140

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.