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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MSS1  -  Mss1p

Saccharomyces cerevisiae S288c

Synonyms: PET53, YM9711.13C, YMR023C, tRNA modification GTPase MSS1, mitochondrial
 
 
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High impact information on MSS1

  • Furthermore, when MTO1 or MSS1, which are responsible for the C5 substituent of the modified uridine, was disrupted along with MTU1, a much more severe reduction in mitochondrial activity was observed [1].
  • Comparison of the MSS1 putative protein with data libraries revealed that it contains, in its second half, the consensus sequences characteristic of GTP binding proteins and is very homologous to the bacterial "genes 50K" [2].
  • Mutations in the MSS1 gene render the yeast cells respiratory deficient only in the presence of the PR454 mutation (paromomycin resistance) in the mitochondrial 15 S ribosomal RNA gene [2].

References

  1. Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases. Umeda, N., Suzuki, T., Yukawa, M., Ohya, Y., Shindo, H., Watanabe, K., Suzuki, T. J. Biol. Chem. (2005) [Pubmed]
  2. MSS1, a nuclear-encoded mitochondrial GTPase involved in the expression of COX1 subunit of cytochrome c oxidase. Decoster, E., Vassal, A., Faye, G. J. Mol. Biol. (1993) [Pubmed]
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