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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MTO1  -  Mto1p

Saccharomyces cerevisiae S288c

Synonyms: IPS1, Mitochondrial translation optimization protein 1, YGL236C
 
 
 
 
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High impact information on MTO1

  • MTO1 codes for a mitochondrial protein required for respiration in paromomycin-resistant mutants of Saccharomyces cerevisiae [1].
  • Mutations in MTO1 express a respiratory defect only in the context of a mitochondrial genome with a paromomycin-resistance allele [1].
  • In a paromomycin-resistant background, mss1 and mto1 mutants are inefficient in processing the mitochondrial COX1 transcript for subunit 1 of cytochrome oxidase [1].
  • The respiratory defective phenotype of mto1 and mss1 mutants is not seen in a paromomycin-sensitive genetic background [1].
  • The mouse MTO1 gene containing 12 exons encodes a 669-residue protein with a strong homology to the MTO1-like proteins of bacteria and yeast, related to tRNA modification [2].

References

  1. MTO1 codes for a mitochondrial protein required for respiration in paromomycin-resistant mutants of Saccharomyces cerevisiae. Colby, G., Wu, M., Tzagoloff, A. J. Biol. Chem. (1998) [Pubmed]
  2. Identification and characterization of mouse MTO1 gene related to mitochondrial tRNA modification. Li, R., Li, X., Yan, Q., Qin Mo, J., Guan, M.X. Biochim. Biophys. Acta (2003) [Pubmed]
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