The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Estomycin     (2R,3S,4R,5R,6R)-5-amino-6- [(2R,3S,4R,6S)...

Synonyms: Humatin, Humycin, catenulin, Gabromycin, Gabbromycin, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Neomycin E


Psychiatry related information on Neomycin E


High impact information on Neomycin E

  • GCN1 expression conferred sensitivity to paromomycin in a manner dependent on its ribosome binding domain, supporting the idea that GCN1 binds near the ribosomal acceptor site to promote GCN2 activation by uncharged tRNA [7].
  • The mof4-1 strain is more sensitive to the aminoglycoside antibiotic paromomycin than a upf1 delta strain, and frameshifting efficiency increases in a mof4-1 strain grown in the presence of this drug [8].
  • Chemical probing of mutant and wild-type ribosomes in the presence of paromomycin indicates that interactions between the antibiotic and 16S rRNA in mutant ribosomes are disrupted [9].
  • We have injected cloned copies of the micronuclear rDNA that have been altered in vitro into developing macronuclei and obtained transformants that express the paromomycin-resistant phenotype specified by the injected rDNA [10].
  • Molecular analysis of paromomycin-resistant embryogenic calli and of plants regenerated from these calli, confirmed the stable integration of bombarded DNA into the cassava genome [11].

Chemical compound and disease context of Neomycin E


Biological context of Neomycin E


Anatomical context of Neomycin E


Associations of Neomycin E with other chemical compounds


Gene context of Neomycin E

  • Mutations in the MSS1 gene render the yeast cells respiratory deficient only in the presence of the PR454 mutation (paromomycin resistance) in the mitochondrial 15 S ribosomal RNA gene [32].
  • However, disruption of NCL1 leads to increased sensitivity to the antibiotic paromomycin [33].
  • Expression of the SSB1 gene from C. albicans, which codes for a member of the 70-kDa heat shock protein family, in S. cerevisiae ssb1 ssb2 double mutant complements the mutant phenotype (poor growth particularly at low temperature, and sensitivity to certain protein synthesis inhibitors, such as paromomycin) [34].
  • Paromomycin and the prion [PSI+], which reduce translational fidelity, do not increase GCN4 expression to induce the suppression phenotype and in fact reduce derepression. eEF1A mutations that reduce translation, however, reduce expression of GCN4 under non-starvation conditions [35].
  • MTO1 codes for a mitochondrial protein required for respiration in paromomycin-resistant mutants of Saccharomyces cerevisiae [36].

Analytical, diagnostic and therapeutic context of Neomycin E


  1. Occlusive paromomycin for cutaneous leishmaniasis. Bryceson, A.D. Lancet (1997) [Pubmed]
  2. The ribosome-bound chaperones RAC and Ssb1/2p are required for accurate translation in Saccharomyces cerevisiae. Rakwalska, M., Rospert, S. Mol. Cell. Biol. (2004) [Pubmed]
  3. Prospective trial of paromomycin for cryptosporidiosis in AIDS. Flanigan, T.P., Ramratnam, B., Graeber, C., Hellinger, J., Smith, D., Wheeler, D., Hawley, P., Heath-Chiozzi, M., Ward, D.J., Brummitt, C., Turner, J. Am. J. Med. (1996) [Pubmed]
  4. An antibiotic-binding motif of an RNA fragment derived from the A-site-related region of Escherichia coli 16S rRNA. Miyaguchi, H., Narita, H., Sakamoto, K., Yokoyama, S. Nucleic Acids Res. (1996) [Pubmed]
  5. Treatment of cryptosporidiosis with paromomycin. A report of five cases. Armitage, K., Flanigan, T., Carey, J., Frank, I., MacGregor, R.R., Ross, P., Goodgame, R., Turner, J. Arch. Intern. Med. (1992) [Pubmed]
  6. Paromomycin therapy of endemic amebiasis in homosexual men. Sullam, P.M., Slutkin, G., Gottlieb, A.B., Mills, J. Sexually transmitted diseases. (1986) [Pubmed]
  7. Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells. Sattlegger, E., Hinnebusch, A.G. EMBO J. (2000) [Pubmed]
  8. Mof4-1 is an allele of the UPF1/IFS2 gene which affects both mRNA turnover and -1 ribosomal frameshifting efficiency. Cui, Y., Dinman, J.D., Peltz, S.W. EMBO J. (1996) [Pubmed]
  9. Mutations in 16S ribosomal RNA disrupt antibiotic--RNA interactions. De Stasio, E.A., Moazed, D., Noller, H.F., Dahlberg, A.E. EMBO J. (1989) [Pubmed]
  10. Identifying functional regions of rRNA by insertion mutagenesis and complete gene replacement in Tetrahymena thermophila. Sweeney, R., Yao, M.C. EMBO J. (1989) [Pubmed]
  11. Regeneration of transgenic cassava plants (Manihot esculenta Crantz) from microbombarded embryogenic suspension cultures. Schöpke, C., Taylor, N., Cárcamo, R., Konan, N.K., Marmey, P., Henshaw, G.G., Beachy, R.N., Fauquet, C. Nat. Biotechnol. (1996) [Pubmed]
  12. Successful treatment of AIDS-related cryptosporidial sclerosing cholangitis. Hamour, A.A., Bonnington, A., Hawthorne, B., Wilkins, E.G. AIDS (1993) [Pubmed]
  13. Epidemic visceral leishmaniasis in Sudan: a randomized trial of aminosidine plus sodium stibogluconate versus sodium stibogluconate alone. Seaman, J., Pryce, D., Sondorp, H.E., Moody, A., Bryceson, A.D., Davidson, R.N. J. Infect. Dis. (1993) [Pubmed]
  14. Aph(3')-IIc, an Aminoglycoside Resistance Determinant from Stenotrophomonas maltophilia. Okazaki, A., Avison, M.B. Antimicrob. Agents Chemother. (2007) [Pubmed]
  15. Evaluation of high-dose regimen of paromomycin against cryptosporidiosis in the dexamethasone-treated rat model. Verdon, R., Polianski, J., Gaudebout, C., Marche, C., Garry, L., Carbon, C., Pocidalo, J.J. Antimicrob. Agents Chemother. (1995) [Pubmed]
  16. In vivo activity of paromomycin against susceptible and multidrug-resistant Mycobacterium tuberculosis and M. avium complex strains. Kanyok, T.P., Reddy, M.V., Chinnaswamy, J., Danziger, L.H., Gangadharam, P.R. Antimicrob. Agents Chemother. (1994) [Pubmed]
  17. Efficient mass transformation of Tetrahymena thermophila by electroporation of conjugants. Gaertig, J., Gorovsky, M.A. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  18. Circular ribosomal DNA plasmids transform Tetrahymena thermophila by homologous recombination with endogenous macronuclear ribosomal DNA. Yu, G.L., Hasson, M., Blackburn, E.H. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  19. The upf3 protein is a component of the surveillance complex that monitors both translation and mRNA turnover and affects viral propagation. Ruiz-Echevarría, M.J., Yasenchak, J.M., Han, X., Dinman, J.D., Peltz, S.W. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  20. Various effects of paromomycin on tmRNA-directed trans-translation. Takahashi, T., Konno, T., Muto, A., Himeno, H. J. Biol. Chem. (2003) [Pubmed]
  21. The nucleotide sequence of the 17S ribosomal RNA gene of Tetrahymena thermophila and the identification of point mutations resulting in resistance to the antibiotics paromomycin and hygromycin. Spangler, E.A., Blackburn, E.H. J. Biol. Chem. (1985) [Pubmed]
  22. A biochemical basis for the inherited susceptibility to aminoglycoside ototoxicity. Guan, M.X., Fischel-Ghodsian, N., Attardi, G. Hum. Mol. Genet. (2000) [Pubmed]
  23. Saccharomyces cerevisiae Nip7p is required for efficient 60S ribosome subunit biogenesis. Zanchin, N.I., Roberts, P., DeSilva, A., Sherman, F., Goldfarb, D.S. Mol. Cell. Biol. (1997) [Pubmed]
  24. Protection by antibiotics against experimental focal cholangitis produced in mice by a schistosomicidal isothiocyanate. Batzinger, R.P., Bueding, E., Popper, H. Hepatology (1981) [Pubmed]
  25. Identification of the paromomycin-resistance mutation in the 15 S rRNA gene of yeast mitochondria. Li, M., Tzagoloff, A., Underbrink-Lyon, K., Martin, N.C. J. Biol. Chem. (1982) [Pubmed]
  26. Suppression of a nonsense mutation in mammalian cells in vivo by the aminoglycoside antibiotics G-418 and paromomycin. Burke, J.F., Mogg, A.E. Nucleic Acids Res. (1985) [Pubmed]
  27. Positive and negative control of multidrug resistance by the Sit4 protein phosphatase in Kluyveromyces lactis. Chen, X.J., Bauer, B.E., Kuchler, K., Clark-Walker, G.D. J. Biol. Chem. (2000) [Pubmed]
  28. In vivo interference of paromomycin with mitochondrial activity of Leishmania. Maarouf, M., de Kouchkovsky, Y., Brown, S., Petit, P.X., Robert-Gero, M. Exp. Cell Res. (1997) [Pubmed]
  29. Tobramycin adenylyltransferase: a new aminoglycoside-inactivating enzyme from Staphylococcus epidermidis. Santanam, P., Kayser, F.H. J. Infect. Dis. (1976) [Pubmed]
  30. Protection of guinea pigs against cutaneous leishmaniasis by combined infection and chemotherapy. El-On, J., Witztum, A., Schnur, L.F. Infect. Immun. (1986) [Pubmed]
  31. Comparative efficacy evaluation of dicationic carbazole compounds, nitazoxanide, and paromomycin against Cryptosporidium parvum infections in a neonatal mouse model. Blagburn, B.L., Drain, K.L., Land, T.M., Kinard, R.G., Moore, P.H., Lindsay, D.S., Patrick, D.A., Boykin, D.W., Tidwell, R.R. Antimicrob. Agents Chemother. (1998) [Pubmed]
  32. MSS1, a nuclear-encoded mitochondrial GTPase involved in the expression of COX1 subunit of cytochrome c oxidase. Decoster, E., Vassal, A., Faye, G. J. Mol. Biol. (1993) [Pubmed]
  33. NCL1, a novel gene for a non-essential nuclear protein in Saccharomyces cerevisiae. Wu, P., Brockenbrough, J.S., Paddy, M.R., Aris, J.P. Gene (1998) [Pubmed]
  34. Complementation of Saccharomyces cerevisiae mutations in genes involved in translation and protein folding (EFB1 and SSB1) with Candida albicans cloned genes. Maneu, V., Roig, P., Gozalbo, D. Res. Microbiol. (2000) [Pubmed]
  35. Interplay between GCN2 and GCN4 expression, translation elongation factor 1 mutations and translational fidelity in yeast. Magazinnik, T., Anand, M., Sattlegger, E., Hinnebusch, A.G., Kinzy, T.G. Nucleic Acids Res. (2005) [Pubmed]
  36. MTO1 codes for a mitochondrial protein required for respiration in paromomycin-resistant mutants of Saccharomyces cerevisiae. Colby, G., Wu, M., Tzagoloff, A. J. Biol. Chem. (1998) [Pubmed]
  37. Intestinal function and injury in acquired immunodeficiency syndrome-related cryptosporidiosis. Goodgame, R.W., Kimball, K., Ou, C.N., White, A.C., Genta, R.M., Lifschitz, C.H., Chappell, C.L. Gastroenterology (1995) [Pubmed]
  38. Transformation of Tetrahymena thermophila by microinjection of a foreign gene. Kahn, R.W., Andersen, B.H., Brunk, C.F. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  39. Fluorescence-based approach for detecting and characterizing antibiotic-induced conformational changes in ribosomal RNA: comparing aminoglycoside binding to prokaryotic and eukaryotic ribosomal RNA sequences. Kaul, M., Barbieri, C.M., Pilch, D.S. J. Am. Chem. Soc. (2004) [Pubmed]
  40. Pharmacokinetics of intramuscularly administered aminosidine in healthy subjects. Kanyok, T.P., Killian, A.D., Rodvold, K.A., Danziger, L.H. Antimicrob. Agents Chemother. (1997) [Pubmed]
  41. Chemoprophylaxis of Cryptosporidium parvum infection with paromomycin in kids and immunological study. Mancassola, R., Reperant, J.M., Naciri, M., Chartier, C. Antimicrob. Agents Chemother. (1995) [Pubmed]
WikiGenes - Universities