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Gene Review

PKR1  -  Pkr1p

Saccharomyces cerevisiae S288c

Synonyms: V-type ATPase assembly factor PKR1, YM8564.05, YMR123W
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High impact information on PKR1

  • PKR1 Encodes an Assembly Factor for the Yeast V-Type ATPase [1].
  • Levels of Vph1p in cells lacking Pkr1p are similar to cells unable to assemble a functional V-ATPase due to lack of a V(0) subunit or an endoplasmic reticulum (ER) assembly factor [1].
  • Pkr1p is localized to the membrane of the endoplasmic reticulum [1].
  • The V-ATPase assembled in the absence of Pkr1p is fully functional because the mutant cells are able to weakly acidify their vacuoles [1].


  1. PKR1 Encodes an Assembly Factor for the Yeast V-Type ATPase. Davis-Kaplan, S.R., Compton, M.A., Flannery, A.R., Ward, D.M., Kaplan, J., Stevens, T.H., Graham, L.A. J. Biol. Chem. (2006) [Pubmed]
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