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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

POP3  -  Pop3p

Saccharomyces cerevisiae S288c

Synonyms: N0586, RNA-processing protein POP3, RNases MRP/P 22.6 kDa subunit, Ribonucleases P/MRP protein subunit POP3, YNL282W
 
 
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High impact information on POP3

  • A genetic screen for mutants which are synthetically lethal (sl) with a temperature-sensitive (ts) mutation in the RNA component of RNase MRP (rrp2-1) identified an essential gene, POP3, which encodes a basic protein of 22.6 kDa predicted molecular weight [1].
  • Immunoprecipitation of epitope-tagged Pop3p co-precipitates the RNA components of both RNase MRP and RNase P. Pop3p is, therefore, a common component of both RNPs and is required for their enzymatic functions in vivo [1].
  • We suggest that this motif is a binding site for the Pop3/Rpp38 proteins and we discuss other structural features of the RNA subunit and possible relationships to the protein subunit repertoire [2].
 

Biological context of POP3

  • The Pop3p depletion phenotype resembles those previously described for mutations in components of RNase MRP and RNase P (rrp2-1, rpr1-1 and pop1-1) [1].
 

Other interactions of POP3

  • Pop3p is essential for the activity of the RNase MRP and RNase P ribonucleoproteins in vivo [1].

References

  1. Pop3p is essential for the activity of the RNase MRP and RNase P ribonucleoproteins in vivo. Dichtl, B., Tollervey, D. EMBO J. (1997) [Pubmed]
  2. Inventory and analysis of the protein subunits of the ribonucleases P and MRP provides further evidence of homology between the yeast and human enzymes. Rosenblad, M.A., L??pez, M.D., Piccinelli, P., Samuelsson, T. Nucleic Acids Res. (2006) [Pubmed]
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