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Gene Review:

CDC14B - cell division cycle 14B

Homo sapiens

Synonyms: CDC14 cell division cycle 14 homolog B, CDC14B3, Cdc14B1, Cdc14B2, Dual specificity protein phosphatase CDC14B, ...

Cho, H.P. et al., Dryden, S.C. et al., Jiménez, J. et al., Bose, S. et al.

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High impact information on CDC14B

CDC14B can bind, bundle, and stabilize microtubules in vitro independently of its catalytic activity [1].
Here, we demonstrate that subcellular localization of CDC14B protein is cell cycle regulated [1].
Overexpression of CDC14B resulted in the formation of cytoplasmic CDC14B and microtubule bundles in interphase cells [1].
CDC14B may provoke exit from mitosis coincident with the loss of SIRT2 via ubiquitination and subsequent degradation by the 26S proteasome [2].
Thus, CDC14B is unlikely to be the MSSE gene [3].

Biological context of CDC14B

A CDC14B mutant defective in catalyzing dephosphorylation fails to change the phosphorylation status or abundance of SIRT2 protein [2].
Overexpression of the human CDC14A and CDC14B genes complemented, although very poorly, S. cerevisiae cdc15-lyt1 and dbf2-2 mutants, suggesting a conserved function of these genes throughout phylogeny [4].

References

The dual-specificity phosphatase CDC14B bundles and stabilizes microtubules. Cho, H.P., Liu, Y., Gomez, M., Dunlap, J., Tyers, M., Wang, Y. Mol. Cell. Biol. (2005) [Pubmed]
Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. Dryden, S.C., Nahhas, F.A., Nowak, J.E., Goustin, A.S., Tainsky, M.A. Mol. Cell. Biol. (2003) [Pubmed]
The elusive multiple self-healing squamous epithelioma (MSSE) gene: further mapping, analysis of candidates, and loss of heterozygosity. Bose, S., Morgan, L.J., Booth, D.R., Goudie, D.R., Ferguson-Smith, M.A., Richards, F.M. Oncogene (2006) [Pubmed]
A single-copy suppressor of the Saccharomyces cerevisae late-mitotic mutants cdc15 and dbf2 is encoded by the Candida albicans CDC14 gene. Jiménez, J., Cid, V.J., Nombela, C., Sánchez, M. Yeast (2001) [Pubmed]

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CDC14B	Bos taurus
CDC14B	Canis lupus familiaris
CDC14B	Gallus gallus
CDC14B	Macaca mulatta
Cdc14b	Mus musculus
CDC14B	Pan troglodytes
Cdc14b	Rattus norvegicus
cdc14b	Xenopus (Silurana) tropicalis

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