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Gene Review

PSY2  -  Psy2p

Saccharomyces cerevisiae S288c

Synonyms: N1366, PP4R3, Serine/threonine-protein phosphatase 4 regulatory subunit 3, YNL201C
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High impact information on PSY2

  • A genome-wide screen in Saccharomyces cerevisiae previously identified PPH3 and PSY2 among the top 20 genes conferring resistance to these anticancer agents [1].
  • PP4cs is comprised of the catalytic subunit PP4C; a known regulatory subunit, PP4R2; and a novel protein that we termed PP4R3 [2].
  • The Saccharomyces cerevisiae PP4R3 ortholog Psy2 was identified previously in a screen for sensitivity to the DNA-damaging agent and anticancer drug cisplatin [2].
  • Tof1 is known to be involved in stabilizing stalled replication forks and our data suggest that Wss1 and Psy2 similarly function to stabilize or process stalled or collapsed replication forks [3].

Biological context of PSY2


Other interactions of PSY2

  • A yeast two-hybrid screen identified a potential physical interaction between Wss1 and both Psy2 and Tof1 [3].


  1. The Saccharomyces cerevisiae orthologue of the human protein phosphatase 4 core regulatory subunit R2 confers resistance to the anticancer drug cisplatin. Hastie, C.J., Vázquez-Martin, C., Philp, A., Stark, M.J., Cohen, P.T. FEBS J. (2006) [Pubmed]
  2. A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. Gingras, A.C., Caballero, M., Zarske, M., Sanchez, A., Hazbun, T.R., Fields, S., Sonenberg, N., Hafen, E., Raught, B., Aebersold, R. Mol. Cell Proteomics (2005) [Pubmed]
  3. Coordinated functions of WSS1, PSY2 and TOF1 in the DNA damage response. O'Neill, B.M., Hanway, D., Winzeler, E.A., Romesberg, F.E. Nucleic Acids Res. (2004) [Pubmed]
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