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Gene Review:

NIS1 - Nis1p

Saccharomyces cerevisiae S288c

Synonyms: JIP1, Jumonji domain-interacting protein 1, N2337, Neck protein interacting with septins protein 1, Protein NIS1, ...

Iwase, M. et al.

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High impact information on NIS1

NAP1 was isolated by two-hybrid screening using NIS1 as bait [1].
Nis1 was found to bind Gin4 and Kcc4 in the two-hybrid assay [1].
GFP-Nis1 is localized in the nucleus throughout the cell cycle and in the bud neck at G2/M phase in a septin-dependent manner [1].
Physical interaction between Nis1 and Shs1 in vivo was confirmed by a co-immunoprecipitation experiment [1].
Nis1 was phosphorylated throughout the cell cycle and was less abundant in G2/M phase [1].

Analytical, diagnostic and therapeutic context of NIS1

Nis1 interacts with all septins in the two-hybrid assay system [1].
We detected physical interaction between Nis1 and Nap1 in vivo by a co-immunoprecipitation experiment [1].

References

Nis1 encoded by YNL078W: a new neck protein of Saccharomyces cerevisiae. Iwase, M., Toh-e, A. Genes Genet. Syst. (2001) [Pubmed]

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