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Gene Review

SHS1  -  septin SHS1

Saccharomyces cerevisiae S288c

Synonyms: SEP7, Septation protein 7, Seventh homolog of septin 1, YDL225W
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High impact information on SHS1

  • In vitro studies with purified recombinant proteins demonstrated that Elm1 directly phosphorylates and activates Gin4, which in turn phosphorylates Shs1 [1].
  • Polarized Ssk2p associates with the scaffold protein Spa2p in the bud and Shs1p in the neck, allowing Ssk2p to regulate substrates involved in polarized actin assembly [2].
  • Genetic data support the idea that Shs1 is an important target of Gin4 kinase activity [3].
  • The shs1 mutant cells showed cytokinesis deficiency and Shs1p was localized at the bud neck in budded cells [4].
  • Physical interaction between Nis1 and Shs1 in vivo was confirmed by a co-immunoprecipitation experiment [5].

Biological context of SHS1

  • Taken together, these findings suggest that highly regulated protein-binding events ensure that the Gin4 kinase is activated only during mitosis and only in association with Shs1, a likely in vivo substrate of Gin4 [3].

Other interactions of SHS1


  1. Direct Phosphorylation and Activation of a Nim1-related Kinase Gin4 by Elm1 in Budding Yeast. Asano, S., Park, J.E., Yu, L.R., Zhou, M., Sakchaisri, K., Park, C.J., Kang, Y.H., Thorner, J., Veenstra, T.D., Lee, K.S. J. Biol. Chem. (2006) [Pubmed]
  2. Actin recovery and bud emergence in osmotically stressed cells requires the conserved actin interacting mitogen-activated protein kinase kinase kinase Ssk2p/MTK1 and the scaffold protein Spa2p. Yuzyuk, T., Amberg, D.C. Mol. Biol. Cell (2003) [Pubmed]
  3. Cell cycle-dependent assembly of a Gin4-septin complex. Mortensen, E.M., McDonald, H., Yates, J., Kellogg, D.R. Mol. Biol. Cell (2002) [Pubmed]
  4. Shs1p: a novel member of septin that interacts with spa2p, involved in polarized growth in saccharomyces cerevisiae. Mino, A., Tanaka, K., Kamei, T., Umikawa, M., Fujiwara, T., Takai, Y. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  5. Nis1 encoded by YNL078W: a new neck protein of Saccharomyces cerevisiae. Iwase, M., Toh-e, A. Genes Genet. Syst. (2001) [Pubmed]
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