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Gene Review:

ARK1 - Ark1p

Saccharomyces cerevisiae S288c

Synonyms: Actin-regulating kinase 1, N2823, YNL020C

Cope, M.J. et al., Henry, K.R. et al., Hopper, N.A. et al., Smythe, E. et al.

Smythe, Ayscough,

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High impact information on ARK1

ARK-1 inhibits LET-23-mediated ovulation, a RAS-independent function [1].
Ark1p and a second yeast protein, Prk1p, contain NH2-terminal kinase domains that are 70% identical [2].
Elevated levels of either Ark1p or Prk1p caused a number of actin and cell morphological defects that were not observed when the kinase-dead versions were overexpressed instead [2].

Biological context of ARK1

Lack of both Ark1p and Prk1p resulted in the formation of large cytoplasmic actin clumps and severe defects in cell growth [2].
The Ark1/Prk1 family of protein kinases. Regulators of endocytosis and the actin skeleton [3].

Other interactions of ARK1

Recently, members of a new kinase family, the Ark/Prk kinases, which include mammalian AAK1 and GAK as well as yeast Prk1p, Ark1p, and Akl1p, were shown to regulate components of the endocytic machinery [4].

Analytical, diagnostic and therapeutic context of ARK1

ARK-1 physically interacts with SEM-5 in the yeast two-hybrid assay [1].

References

ARK-1 inhibits EGFR signaling in C. elegans. Hopper, N.A., Lee, J., Sternberg, P.W. Mol. Cell (2000) [Pubmed]
Novel protein kinases Ark1p and Prk1p associate with and regulate the cortical actin cytoskeleton in budding yeast. Cope, M.J., Yang, S., Shang, C., Drubin, D.G. J. Cell Biol. (1999) [Pubmed]
The Ark1/Prk1 family of protein kinases. Regulators of endocytosis and the actin skeleton. Smythe, E., Ayscough, K.R. EMBO Rep. (2003) [Pubmed]
The actin-regulating kinase Prk1p negatively regulates Scd5p, a suppressor of clathrin deficiency, in actin organization and endocytosis. Henry, K.R., D'Hondt, K., Chang, J.S., Nix, D.A., Cope, M.J., Chan, C.S., Drubin, D.G., Lemmon, S.K. Curr. Biol. (2003) [Pubmed]

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