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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ALG12  -  dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol...

Saccharomyces cerevisiae S288c

Synonyms: Asparagine-linked glycosylation protein 12, Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase, Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase, ECM39, Extracellular mutant protein 39, ...
 
 
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High impact information on ALG12

  • We have identified loss-of-function alleles of ALG12, encoding a mannosyltransferase, as suppressors of a temperature-sensitive mutation in the gene encoding the FXFG-nucleoporin NUP1 [1].
  • We observe that nup1Delta cells import nucleophilic proteins more efficiently when ALG12 is absent, suggesting that glycosylation may influence nuclear transport [1].
  • The Saccharomyces cerevisiae alg (asparagine-linked glycosylation) mutants fail to synthesize oligosaccharide lipid properly, and the alg12 mutant accumulates a Man(7)GlcNAc(2)-PP-Dol intermediate [2].
  • We report on the identification and characterization of the ALG12 locus encoding a novel mannosyltransferase responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2 [3].

References

  1. Nuclear pore complex function in Saccharomyces cerevisiae is influenced by glycosylation of the transmembrane nucleoporin Pom152p. Belanger, K.D., Gupta, A., MacDonald, K.M., Ott, C.M., Hodge, C.A., Cole, C.M., Davis, L.I. Genetics (2005) [Pubmed]
  2. The Saccharomyces cerevisiae alg12delta mutant reveals a role for the middle-arm alpha1,2Man- and upper-arm alpha1,2Manalpha1,6Man- residues of Glc3Man9GlcNAc2-PP-Dol in regulating glycoprotein glycan processing in the endoplasmic reticulum and Golgi apparatus. Cipollo, J.F., Trimble, R.B. Glycobiology (2002) [Pubmed]
  3. Ordered assembly of the asymmetrically branched lipid-linked oligosaccharide in the endoplasmic reticulum is ensured by the substrate specificity of the individual glycosyltransferases. Burda, P., Jakob, C.A., Beinhauer, J., Hegemann, J.H., Aebi, M. Glycobiology (1999) [Pubmed]
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