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Gene Review:

SOL1 - Sol1p

Saccharomyces cerevisiae S288c

Synonyms: 6-phosphogluconolactonase-like protein 1, N3291, YNR034W

Stanford, D.R. et al., Atir-Lande, A. et al., Shen, W.C. et al.

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High impact information on SOL1

However, ectopic expression and deletion of SOL1 indicate a role for this gene in C. albicans morphogenesis [1].
SOL1, the founding member of the S. cerevisiae SOL family, was previously identified as a multi-copy suppressor of the los1 defect in tRNA-mediated nonsense suppression [2].
SOL1-SOL4 are homologous to genes encoding 6-phosphogluconolactonase (6Pgl) involved in the pentose phosphate pathway [2].

Regulatory relationships of SOL1

Thus, LOS1 appears to positively regulate SOL1 [3].

References

Role for the SCFCDC4 ubiquitin ligase in Candida albicans morphogenesis. Atir-Lande, A., Gildor, T., Kornitzer, D. Mol. Biol. Cell (2005) [Pubmed]
Division of labor among the yeast Sol proteins implicated in tRNA nuclear export and carbohydrate metabolism. Stanford, D.R., Whitney, M.L., Hurto, R.L., Eisaman, D.M., Shen, W.C., Hopper, A.K. Genetics (2004) [Pubmed]
Los1p, involved in yeast pre-tRNA splicing, positively regulates members of the SOL gene family. Shen, W.C., Stanford, D.R., Hopper, A.K. Genetics (1996) [Pubmed]

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