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Gene Review:

BIO5 - Bio5p

Saccharomyces cerevisiae S288c

Synonyms: 7-keto 8-aminopelargonic acid transporter, KAPA transporter, N3502, YNR056C

Weider, M. et al., Bellí, G. et al., Phalip, V. et al.

Phalip, Kuhn, Lemoine, Jeltsch,

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High impact information on BIO5

Vhr1p, a New Transcription Factor from Budding Yeast, Regulates Biotin-dependent Expression of VHT1 and BIO5 [1].
Deltavhr1 deletion mutants fail to induce BIO5 on low biotin concentrations [1].
Bio5p mediates the transport of 7-keto-8-aminopelargonic acid across the yeast plasma membrane, a compound that is used as a precursor in biotin biosynthesis [1].
BIO5 is another Aft1-dependent gene induced both upon iron deprivation and in Deltagrx5 cells; this links iron and biotin metabolism [2].
A novel gene, BIO5 (YNR056c), is present immediately downstream from BIO4 [3].

References

Vhr1p, a New Transcription Factor from Budding Yeast, Regulates Biotin-dependent Expression of VHT1 and BIO5. Weider, M., Machnik, A., Klebl, F., Sauer, N. J. Biol. Chem. (2006) [Pubmed]
Saccharomyces cerevisiae glutaredoxin 5-deficient cells subjected to continuous oxidizing conditions are affected in the expression of specific sets of genes. Bellí, G., Molina, M.M., García-Martínez, J., Pérez-Ortín, J.E., Herrero, E. J. Biol. Chem. (2004) [Pubmed]
Characterization of the biotin biosynthesis pathway in Saccharomyces cerevisiae and evidence for a cluster containing BIO5, a novel gene involved in vitamer uptake. Phalip, V., Kuhn, I., Lemoine, Y., Jeltsch, J.M. Gene (1999) [Pubmed]

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