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Gene Review

BEM4  -  Bem4p

Saccharomyces cerevisiae S288c

Synonyms: Bud emergence protein 4, P2561, YPL161C
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High impact information on BEM4

  • The coiled-coil domain is important for interaction with Cdc3 and Bem4 [1].
  • ROM7/BEM4 encodes a novel protein that interacts with the Rho1p small GTP-binding protein in Saccharomyces cerevisiae [2].
  • Disruption of BEM4 resulted in the cold- and temperature-sensitive growth phenotypes, and cells of the deltabem4 mutant showed abnormal morphology, suggesting that BEM4 is involved in the budding process [2].
  • Cells from which BEM4 was deleted were inviable at 37 degrees C. These cells became unbudded, large, and round, consistent with a model in which Bem4p acts together with Cdc42p in polarity establishment and bud emergence [3].

Other interactions of BEM4

  • This finding suggests that Bem4p also affects Rho1p function [3].


  1. Molecular dissection of a yeast septin: distinct domains are required for septin interaction, localization, and function. Casamayor, A., Snyder, M. Mol. Cell. Biol. (2003) [Pubmed]
  2. ROM7/BEM4 encodes a novel protein that interacts with the Rho1p small GTP-binding protein in Saccharomyces cerevisiae. Hirano, H., Tanaka, K., Ozaki, K., Imamura, H., Kohno, H., Hihara, T., Kameyama, T., Hotta, K., Arisawa, M., Watanabe, T., Qadota, H., Ohya, Y., Takai, Y. Mol. Cell. Biol. (1996) [Pubmed]
  3. Identification of the bud emergence gene BEM4 and its interactions with rho-type GTPases in Saccharomyces cerevisiae. Mack, D., Nishimura, K., Dennehey, B.K., Arbogast, T., Parkinson, J., Toh-e, A., Pringle, J.R., Bender, A., Matsui, Y. Mol. Cell. Biol. (1996) [Pubmed]
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