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Gene Review

DIG1  -  Dig1p

Saccharomyces cerevisiae S288c

Synonyms: Down-regulator of invasive growth 1, P7102.02, RST1, Regulator of STE12 protein 1, Regulator of sterile twelve 1, ...
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High impact information on DIG1

  • DIG2 is pheromone-inducible, whereas DIG1 is constitutively expressed [1].
  • Ste12 also binds specifically to GST-Dig1 in the absence of any other yeast protein [1].
  • High-level expression of Dig1 suppresses invasive growth and also causes cells to appear more resistant to pheromone-imposed cell cycle arrest [1].
  • Furthermore, disruption of dig1, but not dig2, causes elevated transcriptional activation by a LexA-Ste12p(216-688) fusion [2].
  • The phenotype of rst1 rst2 cells required Ste12 function, but did not require the function of upstream kinases [3].

Biological context of DIG1

  • Expression of DIG2, but not DIG1, from a GAL promoter inhibits transcriptional activation by an Ste12p DBD-VP16 fusion [2].
  • Homozygous deletion of both RST1 and RST2 (rst-) causes a/alpha diploid cells constitutively to express a-specific genes and mate preferentially as a-cells [4].
  • The encoded protein has a single DNA binding homeodomain but lacks both a C2H2 zinc finger DNA binding domain and an apparent Dig1/Dig2 regulatory motif [5].

Analytical, diagnostic and therapeutic context of DIG1


  1. Two novel targets of the MAP kinase Kss1 are negative regulators of invasive growth in the yeast Saccharomyces cerevisiae. Cook, J.G., Bardwell, L., Kron, S.J., Thorner, J. Genes Dev. (1996) [Pubmed]
  2. Two regulators of Ste12p inhibit pheromone-responsive transcription by separate mechanisms. Olson, K.A., Nelson, C., Tai, G., Hung, W., Yong, C., Astell, C., Sadowski, I. Mol. Cell. Biol. (2000) [Pubmed]
  3. Regulation of the mating pheromone and invasive growth responses in yeast by two MAP kinase substrates. Tedford, K., Kim, S., Sa, D., Stevens, K., Tyers, M. Curr. Biol. (1997) [Pubmed]
  4. Rst1 and Rst2 are required for the a/alpha diploid cell type in yeast. Gelli, A. Mol. Microbiol. (2002) [Pubmed]
  5. Candida glabrata STE12 is required for wild-type levels of virulence and nitrogen starvation induced filamentation. Calcagno, A.M., Bignell, E., Warn, P., Jones, M.D., Denning, D.W., Mühlschlegel, F.A., Rogers, T.R., Haynes, K. Mol. Microbiol. (2003) [Pubmed]
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