The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt

Table of contents

About

Terms

 

Gene Review: 

GOS1  -  Gos1p

Saccharomyces cerevisiae S288c

Synonyms: Golgi SNAP receptor complex member 1, Golgi SNARE protein 1, Protein transport protein GOS1, YHL031C
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on GOS1

  • Localization of VFT to the Golgi requires Ypt6p, but is unaffected in gos1 and tlg1 mutants, in which late Golgi integral membrane proteins, including SNAREs, are mislocalized [1].
  • Assembly of the ER to Golgi SNARE complex requires Uso1p [2].
  • Multicopy plasmids expressing v-SNAREs Gos1p or Ykt6p, but not other v- and t-SNAREs, partially suppressed phenotypes of ric1Delta and ypt6Delta cells [3].
  • Binding of Sly1 to Sed5 enhances formation of the yeast early Golgi SNARE complex [4].
  • Deletion of GOS1 results in viable haploids with modest growth and secretory defects [5].
 

Biological context of GOS1

  • Close examination of the secretory phenotype of GOS1-disrupted cells suggests that Gos1p may play a role in multiple transport steps, specifically ER-Golgi and/or intra-Golgi transport [5].

References

  1. An effector of Ypt6p binds the SNARE Tlg1p and mediates selective fusion of vesicles with late Golgi membranes. Siniossoglou, S., Pelham, H.R. EMBO J. (2001) [Pubmed]
  2. Assembly of the ER to Golgi SNARE complex requires Uso1p. Sapperstein, S.K., Lupashin, V.V., Schmitt, H.D., Waters, M.G. J. Cell Biol. (1996) [Pubmed]
  3. Ric1p and the Ypt6p GTPase function in a common pathway required for localization of trans-Golgi network membrane proteins. Bensen, E.S., Yeung, B.G., Payne, G.S. Mol. Biol. Cell (2001) [Pubmed]
  4. Binding of Sly1 to Sed5 enhances formation of the yeast early Golgi SNARE complex. Kosodo, Y., Noda, Y., Adachi, H., Yoda, K. J. Cell. Sci. (2002) [Pubmed]
  5. Gos1p, a Saccharomyces cerevisiae SNARE protein involved in Golgi transport. McNew, J.A., Coe, J.G., Søgaard, M., Zemelman, B.V., Wimmer, C., Hong, W., Söllner, T.H. FEBS Lett. (1998) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities