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Gene Review

GOS1  -  Gos1p

Saccharomyces cerevisiae S288c

Synonyms: Golgi SNAP receptor complex member 1, Golgi SNARE protein 1, Protein transport protein GOS1, YHL031C
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High impact information on GOS1

  • Localization of VFT to the Golgi requires Ypt6p, but is unaffected in gos1 and tlg1 mutants, in which late Golgi integral membrane proteins, including SNAREs, are mislocalized [1].
  • Assembly of the ER to Golgi SNARE complex requires Uso1p [2].
  • Multicopy plasmids expressing v-SNAREs Gos1p or Ykt6p, but not other v- and t-SNAREs, partially suppressed phenotypes of ric1Delta and ypt6Delta cells [3].
  • Binding of Sly1 to Sed5 enhances formation of the yeast early Golgi SNARE complex [4].
  • Deletion of GOS1 results in viable haploids with modest growth and secretory defects [5].

Biological context of GOS1

  • Close examination of the secretory phenotype of GOS1-disrupted cells suggests that Gos1p may play a role in multiple transport steps, specifically ER-Golgi and/or intra-Golgi transport [5].


  1. An effector of Ypt6p binds the SNARE Tlg1p and mediates selective fusion of vesicles with late Golgi membranes. Siniossoglou, S., Pelham, H.R. EMBO J. (2001) [Pubmed]
  2. Assembly of the ER to Golgi SNARE complex requires Uso1p. Sapperstein, S.K., Lupashin, V.V., Schmitt, H.D., Waters, M.G. J. Cell Biol. (1996) [Pubmed]
  3. Ric1p and the Ypt6p GTPase function in a common pathway required for localization of trans-Golgi network membrane proteins. Bensen, E.S., Yeung, B.G., Payne, G.S. Mol. Biol. Cell (2001) [Pubmed]
  4. Binding of Sly1 to Sed5 enhances formation of the yeast early Golgi SNARE complex. Kosodo, Y., Noda, Y., Adachi, H., Yoda, K. J. Cell. Sci. (2002) [Pubmed]
  5. Gos1p, a Saccharomyces cerevisiae SNARE protein involved in Golgi transport. McNew, J.A., Coe, J.G., Søgaard, M., Zemelman, B.V., Wimmer, C., Hong, W., Söllner, T.H. FEBS Lett. (1998) [Pubmed]
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