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Gene Review

STP2  -  Stp2p

Saccharomyces cerevisiae S288c

Synonyms: Transcription factor STP2, YHR006W
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High impact information on STP2

  • The processing of Stp1p/Stp2p occurs independently of proteasome function and without the apparent involvement of additional components [1].
  • In this study, we report that Asi1 is an integral component of the inner nuclear membrane that maintains the latent characteristics of unprocessed Stp1 and Stp2 [2].
  • Stp1 and Stp2 are homologous transcription factors in yeast that are synthesized as latent cytoplasmic precursors with NH2-terminal regulatory domains [2].
  • A novel genetic screen, specifically designed to search for rare mutations that affect the SPS-sensing pathway, identified the F-box protein Grr1p as an obligatory factor required for Stp1p/Stp2p processing [3].
  • We tested one novel motif prediction of the algorithm and found it to be the binding site of Stp2; it is significantly different from the previously predicted Stp2 binding site [4].

Biological context of STP2


Associations of STP2 with chemical compounds

  • Under the given conditions there appears to be only one pathway for induction with L-citrulline, and this pathway is completely dependent on the SPS component, Ssy1p, and either of the transcription factors, Stp1p and Stp2p [6].

Other interactions of STP2

  • In this paper, we show that Stp2p, a protein with considerable similarity to Stp1p, is also involved in the induction of BAP3 expression [7].
  • Additionally, we have found that a null mutation in the ASI1 (amino acid sensor-independent) gene enables full-length unprocessed Stp1p/Stp2p to enter the nucleus and derepress SPS sensor-dependent genes [3].
  • Two plasma membrane-associated proteins, Ptr3p and Ssy5p, participate in the sensing, which results in cleavage of the transcription factors Stp1p and Stp2p, removing 10 kDa of the N terminus of each of them [8].


  1. Receptor-mediated endoproteolytic activation of two transcription factors in yeast. Andréasson, C., Ljungdahl, P.O. Genes Dev. (2002) [Pubmed]
  2. Asi1 is an inner nuclear membrane protein that restricts promoter access of two latent transcription factors. Boban, M., Zargari, A., Andréasson, C., Heessen, S., Thyberg, J., Ljungdahl, P.O. J. Cell Biol. (2006) [Pubmed]
  3. The N-terminal regulatory domain of Stp1p is modular and, fused to an artificial transcription factor, confers full Ssy1p-Ptr3p-Ssy5p sensor control. Andréasson, C., Ljungdahl, P.O. Mol. Cell. Biol. (2004) [Pubmed]
  4. Discovery, validation, and genetic dissection of transcription factor binding sites by comparative and functional genomics. Gertz, J., Riles, L., Turnbaugh, P., Ho, S.W., Cohen, B.A. Genome Res. (2005) [Pubmed]
  5. Transcriptional regulation of the Saccharomyces cerevisiae amino acid permease gene BAP2. Nielsen, P.S., van den Hazel, B., Didion, T., de Boer, M., Jørgensen, M., Planta, R.J., Kielland-Brandt, M.C., Andersen, H.A. Mol. Gen. Genet. (2001) [Pubmed]
  6. Transcriptional profiling of extracellular amino acid sensing in Saccharomyces cerevisiae and the role of Stp1p and Stp2p. Eckert-Boulet, N., Nielsen, P.S., Friis, C., dos Santos, M.M., Nielsen, J., Kielland-Brandt, M.C., Regenberg, B. Yeast (2004) [Pubmed]
  7. Stp1p, Stp2p and Abf1p are involved in regulation of expression of the amino acid transporter gene BAP3 of Saccharomyces cerevisiae. de Boer, M., Nielsen, P.S., Bebelman, J.P., Heerikhuizen, H., Andersen, H.A., Planta, R.J. Nucleic Acids Res. (2000) [Pubmed]
  8. Constitutive signal transduction by mutant Ssy5p and Ptr3p components of the SPS amino acid sensor system in Saccharomyces cerevisiae. Poulsen, P., Wu, B., Gaber, R.F., Kielland-Brandt, M.C. Eukaryotic Cell (2005) [Pubmed]
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