Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

PAN5 - 2-dehydropantoate 2-reductase PAN5

Saccharomyces cerevisiae S288c

Synonyms: 2-dehydropantoate 2-reductase, KPA reductase, KPR, Ketopantoate reductase, YHR063C

Ottenhof, H.H. et al., Tzschoppe, K. et al.

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Disease relevance of PAN5

We investigated whether Arabidopsis encoded homologues of the remaining two pantothenate biosynthesis enzymes from E. coli, l-aspartate-alpha-decarboxylase (ADC) and ketopantoate reductase (KPR) [1].

High impact information on PAN5

So far no homologs have been identified, except for the product of the S. cerevisiae orf YHR063C, which has some similarity to Cbs2p [2].

References

Organisation of the pantothenate (vitamin B5) biosynthesis pathway in higher plants. Ottenhof, H.H., Ashurst, J.L., Whitney, H.M., Saldanha, S.A., Schmitzberger, F., Gweon, H.S., Blundell, T.L., Abell, C., Smith, A.G. Plant J. (2004) [Pubmed]
Mutational analysis of yeast mitochondrial translational activator Cbs2p and of YHR063Cp, a protein with similarity to Cbs2p. Tzschoppe, K., Krause-Buchholz, U., Rödel, G. Curr. Genet. (1999) [Pubmed]

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