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Gene Review

CBS2  -  Cbs2p

Saccharomyces cerevisiae S288c

Synonyms: CBP7, Cytochrome B translational activator protein CBS2, YD9346.08, YDR197W
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Disease relevance of CBS2


High impact information on CBS2

  • In this paper we characterize a nuclear gene, CBP7, already known to be required for the translation of the cytochrome b transcript; we present further evidence that it is also required as a co-factor in conjunction with the maturases for the efficient processing of their intervening sequences [2].
  • The AMP binding site of the gamma(1) CBS1/CBS2 pair, modeled on the structures of the CBS sequences present in the inosine monophosphate dehydrogenase crystal structure, contains three arginine residues 70, 152, and 171 and His151 [3].
  • The resulting predicted functions include three particularly interesting cases of translation-associated proteins: peptidyl-tRNA hydrolase, a ribosome recycling factor homologue, and a protein similar to cytochrome b translational activator CBS2 [4].
  • Recently, we provided evidence for an interaction of Cbs2p with mitochondrial ribosomes [5].
  • The yeast translational activator protein Cbs2p is imported into mitochondria without obvious proteolytic processing [6].

Biological context of CBS2

  • The results exclude the possibility that suppressor genes have been cloned and confirm the conclusion that both genes, CBS1 and CBS2, specifically are involved in translation of mitochondrial COB RNA [7].
  • In this report, we show that CBS2 is located on chromosome IV and provide genetic evidence that the CBS2 gene encodes a polypeptide [8].
  • The CBS2 gene is transcribed into low abundance mRNA species with a major transcription initiation site located 97 bp upstream from the ATG start codon next to a poly(dA-dT) stretch [8].
  • Here we report on the identification of two unique chromosomal DNA-sequences of 2 kb and 2.3 kb from yeast wild type gene banks which functionally complement cbs1 and cbs2 mutants, respectively [7].
  • The protein is overexpressed in mitochondrial extracts of a transformant carrying the CBS2 gene on a high copy number plasmid, but undetectable in the post-mitochondrial supernatant [1].

Anatomical context of CBS2


Other interactions of CBS2

  • In this article I review available data on CBS1p and CBS2p from the initial detection of the genes up to the current investigations on interacting components and the proteins' topology [9].
  • The yeast nuclear genes CBS1 and CBS2 are both required for translation of the mitochondrial COB transcripts [7].
  • So far no homologs have been identified, except for the product of the S. cerevisiae orf YHR063C, which has some similarity to Cbs2p [10].

Analytical, diagnostic and therapeutic context of CBS2


  1. Identification of CBS2 as a mitochondrial protein in Saccharomyces cerevisiae. Michaelis, U., Rödel, G. Mol. Gen. Genet. (1990) [Pubmed]
  2. CBP7 codes for a co-factor required in conjunction with a mitochondrial maturase for splicing of its cognate intervening sequence. Muroff, I., Tzagoloff, A. EMBO J. (1990) [Pubmed]
  3. Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site. Adams, J., Chen, Z.P., Van Denderen, B.J., Morton, C.J., Parker, M.W., Witters, L.A., Stapleton, D., Kemp, B.E. Protein Sci. (2004) [Pubmed]
  4. New protein functions in yeast chromosome VIII. Ouzounis, C., Bork, P., Casari, G., Sander, C. Protein Sci. (1995) [Pubmed]
  5. Saccharomyces cerevisiae translational activator Cbs1p is associated with translationally active mitochondrial ribosomes. Krause-Buchholz, U., Schöbel, K., Lauffer, S., Rödel, G. Biol. Chem. (2005) [Pubmed]
  6. Yeast translational activator Cbs2p: mitochondrial targeting and effect of overexpression. Tzschoppe, K., Kohlwein, S.D., Rödel, G. Biol. Chem. (2000) [Pubmed]
  7. Molecular cloning of the yeast nuclear genes CBS1 and CBS2. Rödel, G., Michaelis, U., Forsbach, V., Kreike, J., Kaudewitz, F. Curr. Genet. (1986) [Pubmed]
  8. Yeast nuclear gene CBS2, required for translational activation of cytochrome b, encodes a basic protein of 45 kDa. Michaelis, U., Schlapp, T., Rödel, G. Mol. Gen. Genet. (1988) [Pubmed]
  9. Translational activator proteins required for cytochrome b synthesis in Saccharomyces cerevisiae. Rödel, G. Curr. Genet. (1997) [Pubmed]
  10. Mutational analysis of yeast mitochondrial translational activator Cbs2p and of YHR063Cp, a protein with similarity to Cbs2p. Tzschoppe, K., Krause-Buchholz, U., Rödel, G. Curr. Genet. (1999) [Pubmed]
  11. Saccharomyces cerevisiae translational activator Cbs2p is associated with mitochondrial ribosomes. Krause-Buchholz, U., Barth, K., Dombrowski, C., Rödel, G. Curr. Genet. (2004) [Pubmed]
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