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Gene Review:

GGA2 - Gga2p

Saccharomyces cerevisiae S288c

Synonyms: ADP-ribosylation factor-binding protein GGA2, Golgi-localized, gamma ear-containing, ARF-binding protein 2, YHR108W

Takatsu, H. et al., Zhdankina, O. et al., Hirst, J. et al.

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High impact information on GGA2

GGA1 and GGA2 are also not associated with each other, although they colocalize on perinuclear membranes [1].
These previously uncharacterized open reading frames, YDR358w and YHR108w, have been named GGA1 and GGA2, respectively [2].
When overexpressed, the proteins, called GGA1, GGA2, and GGA3, localized to the trans-Golgi network (TGN) and often caused fragmentation and vacuolation of the compartment [3].

References

A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome. Hirst, J., Lui, W.W., Bright, N.A., Totty, N., Seaman, M.N., Robinson, M.S. J. Cell Biol. (2000) [Pubmed]
Yeast GGA proteins interact with GTP-bound Arf and facilitate transport through the Golgi. Zhdankina, O., Strand, N.L., Redmond, J.M., Boman, A.L. Yeast (2001) [Pubmed]
Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin. Takatsu, H., Yoshino, K., Nakayama, K. Biochem. Biophys. Res. Commun. (2000) [Pubmed]

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AGOS_AER243W	Ashbya gossypii ATCC 10895
KLLA0E21473g	Kluyveromyces lactis NRRL Y-1140
MGG_00852	Magnaporthe oryzae 70-15
NCU11302	Neurospora crassa OR74A
SPBC25H2.16c	Schizosaccharomyces pombe 972h-

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