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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SPC97  -  Spc97p

Saccharomyces cerevisiae S288c

Synonyms: Spindle pole body component SPC97, YHR172W
 
 
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High impact information on SPC97

  • In this paper we report the identification of SPC97 encoding an essential SPB component that is in association with the SPB substructures that organize the cytoplasmic and nuclear microtubules [1].
  • The spindle pole body component Spc97p interacts with the gamma-tubulin of Saccharomyces cerevisiae and functions in microtubule organization and spindle pole body duplication [1].
  • In contrast, the spc97 alleles are synthetic lethal with spc110 alleles that encode mutations in either the N terminus or the C terminus [2].
  • RESULTS: We have previously shown that the mutant defective in alp4+ (Spc97/GCP2) displays bipolar spindle defects due to a failure in the recruitment of the gamma-TuC on to the spindle pole body (SPB, the centrosome equivalent) [3].
 

Associations of SPC97 with chemical compounds

  • Alanine substitution for any one of these phosphorylated residues, in conjunction with an alanine substitution at residue Ser(36), is lethal in combination with alleles of SPC97, which encodes a component of the Tub4p complex [4].

References

  1. The spindle pole body component Spc97p interacts with the gamma-tubulin of Saccharomyces cerevisiae and functions in microtubule organization and spindle pole body duplication. Knop, M., Pereira, G., Geissler, S., Grein, K., Schiebel, E. EMBO J. (1997) [Pubmed]
  2. A genetic analysis of interactions with Spc110p reveals distinct functions of Spc97p and Spc98p, components of the yeast gamma-tubulin complex. Nguyen, T., Vinh, D.B., Crawford, D.K., Davis, T.N. Mol. Biol. Cell (1998) [Pubmed]
  3. The gamma-tubulin complex protein Alp4 provides a link between the metaphase checkpoint and cytokinesis in fission yeast. Vardy, L., Fujita, A., Toda, T. Genes Cells (2002) [Pubmed]
  4. Yeast Mps1p phosphorylates the spindle pole component Spc110p in the N-terminal domain. Friedman, D.B., Kern, J.W., Huneycutt, B.J., Vinh, D.B., Crawford, D.K., Steiner, E., Scheiltz, D., Yates, J., Resing, K.A., Ahn, N.G., Winey, M., Davis, T.N. J. Biol. Chem. (2001) [Pubmed]
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