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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

HAT2  -  Hat2p

Saccharomyces cerevisiae S288c

Synonyms: Histone acetyltransferase type B subunit 2, YEL056W
 
 
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High impact information on HAT2

  • The activity contains two proteins, Hat1p and Hat2p [1].
  • However, the role for these gene products in chromatin function has been unclear, as deletions of the HAT1 and/or HAT2 gene displayed no obvious phenotype [2].
  • We have analyzed the histone acetyltransferase enzymes obtained from a series of yeast hat1, hat2, and gcn5 single mutants and hat1,hat2 and hat1,gcn5 double mutants [3].
  • Differential display analysis demonstrated that the expression of cell cycle genes encoding DNA ligase (CDC9) and histone acetyltransferase (HAT2) was strongly repressed in FOH-treated cells [4].
 

Biological context of HAT2

 

Associations of HAT2 with chemical compounds

 

Other interactions of HAT2

  • These results indicate that Hat2p could have additional functions in the cell to those of Hat1p [5].

References

  1. The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism. Parthun, M.R., Widom, J., Gottschling, D.E. Cell (1996) [Pubmed]
  2. Type B histone acetyltransferase Hat1p participates in telomeric silencing. Kelly, T.J., Qin, S., Gottschling, D.E., Parthun, M.R. Mol. Cell. Biol. (2000) [Pubmed]
  3. HAT1 and HAT2 proteins are components of a yeast nuclear histone acetyltransferase enzyme specific for free histone H4. Ruiz-García, A.B., Sendra, R., Galiana, M., Pamblanco, M., Pérez-Ortín, J.E., Tordera, V. J. Biol. Chem. (1998) [Pubmed]
  4. Farnesol-induced growth inhibition in Saccharomyces cerevisiae by a cell cycle mechanism. Machida, K., Tanaka, T., Yano, Y., Otani, S., Taniguchi, M. Microbiology (Reading, Engl.) (1999) [Pubmed]
  5. Yeast HAT1 and HAT2 deletions have different life-span and transcriptome phenotypes. Rosaleny, L.E., Antúnez, O., Ruiz-García, A.B., Pérez-Ortín, J.E., Tordera, V. FEBS Lett. (2005) [Pubmed]
  6. The nuclear Hat1p/Hat2p complex: a molecular link between type B histone acetyltransferases and chromatin assembly. Ai, X., Parthun, M.R. Mol. Cell (2004) [Pubmed]
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