Gene Review:
GCN5 - histone acetyltransferase GCN5
Saccharomyces cerevisiae S288c
Synonyms:
AAS104, ADA4, Histone acetyltransferase GCN5, SWI9, YGR252W
- Crystal structure of a GCN5-related N-acetyltransferase: Serratia marcescens aminoglycoside 3-N-acetyltransferase. Wolf, E., Vassilev, A., Makino, Y., Sali, A., Nakatani, Y., Burley, S.K. Cell (1998)
- Stimulation of DNA replication from the polyomavirus origin by PCAF and GCN5 acetyltransferases: acetylation of large T antigen. Xie, A.Y., Bermudez, V.P., Folk, W.R. Mol. Cell. Biol. (2002)
- Adenovirus E1A requires the yeast SAGA histone acetyltransferase complex and associates with SAGA components Gcn5 and Tra1. Kulesza, C.A., Van Buskirk, H.A., Cole, M.D., Reese, J.C., Smith, M.M., Engel, D.A. Oncogene (2002)
- Function and selectivity of bromodomains in anchoring chromatin-modifying complexes to promoter nucleosomes. Hassan, A.H., Prochasson, P., Neely, K.E., Galasinski, S.C., Chandy, M., Carrozza, M.J., Workman, J.L. Cell (2002)
- Global role for chromatin remodeling enzymes in mitotic gene expression. Krebs, J.E., Fry, C.J., Samuels, M.L., Peterson, C.L. Cell (2000)
- Histone H3 specific acetyltransferases are essential for cell cycle progression. Howe, L., Auston, D., Grant, P., John, S., Cook, R.G., Workman, J.L., Pillus, L. Genes Dev. (2001)
- Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors. Marcus, G.A., Silverman, N., Berger, S.L., Horiuchi, J., Guarente, L. EMBO J. (1994)
- GCN5 dependence of chromatin remodeling and transcriptional activation by the GAL4 and VP16 activation domains in budding yeast. Stafford, G.A., Morse, R.H. Mol. Cell. Biol. (2001)
- Mutations in chromatin components suppress a defect of Gcn5 protein in Saccharomyces cerevisiae. Pérez-Martín, J., Johnson, A.D. Mol. Cell. Biol. (1998)
- The Saccharomyces cerevisiae histone acetyltransferase Gcn5 has a role in the photoreactivation and nucleotide excision repair of UV-induced cyclobutane pyrimidine dimers in the MFA2 gene. Teng, Y., Yu, Y., Waters, R. J. Mol. Biol. (2002)
- Nucleosome position-dependent and -independent activation of HIS7 epression in Saccharomyces cerevisiae by different transcriptional activators. Valerius, O., Brendel, C., Wagner, C., Krappmann, S., Thoma, F., Braus, G.H. Eukaryotic Cell (2003)
- The coactivator p/CIP/SRC-3 facilitates retinoic acid receptor signaling via recruitment of GCN5. Brown, K., Chen, Y., Underhill, T.M., Mymryk, J.S., Torchia, J. J. Biol. Chem. (2003)
- Swi/SNF-GCN5-dependent chromatin remodelling determines induced expression of GDH3, one of the paralogous genes responsible for ammonium assimilation and glutamate biosynthesis in Saccharomyces cerevisiae. Avendaño, A., Riego, L., DeLuna, A., Aranda, C., Romero, G., Ishida, C., Vázquez-Acevedo, M., Rodarte, B., Recillas-Targa, F., Valenzuela, L., Zonszein, S., González, A. Mol. Microbiol. (2005)
- Both normal and polyglutamine- expanded ataxin-7 are components of TFTC-type GCN5 histone acetyltransferase- containing complexes. Helmlinger, D., Hardy, S., Eberlin, A., Devys, D., Tora, L. Biochem. Soc. Symp. (2006)
- Global histone acetylation and deacetylation in yeast. Vogelauer, M., Wu, J., Suka, N., Grunstein, M. Nature (2000)
- Histone H3 Ser10 phosphorylation-independent function of Snf1 and Reg1 proteins rescues a gcn5- mutant in HIS3 expression. Liu, Y., Xu, X., Singh-Rodriguez, S., Zhao, Y., Kuo, M.H. Mol. Cell. Biol. (2005)
- ADA1, a novel component of the ADA/GCN5 complex, has broader effects than GCN5, ADA2, or ADA3. Horiuchi, J., Silverman, N., Piña, B., Marcus, G.A., Guarente, L. Mol. Cell. Biol. (1997)
- A targeted histone acetyltransferase can create a sizable region of hyperacetylated chromatin and counteract the propagation of transcriptionally silent chromatin. Chiu, Y.H., Yu, Q., Sandmeier, J.J., Bi, X. Genetics (2003)
- Multiple mechanistically distinct functions of SAGA at the PHO5 promoter. Barbaric, S., Reinke, H., Hörz, W. Mol. Cell. Biol. (2003)
- Absence of Gcn5 HAT activity defines a novel state in the opening of chromatin at the PHO5 promoter in yeast. Gregory, P.D., Schmid, A., Zavari, M., Lui, L., Berger, S.L., Hörz, W. Mol. Cell (1998)
- Contribution of the histone H3 and H4 amino termini to Gcn4p- and Gcn5p-mediated transcription in yeast. Yu, C., Palumbo, M.J., Lawrence, C.E., Morse, R.H. J. Biol. Chem. (2006)
- Sumoylation of the yeast Gcn5 protein. Sterner, D.E., Nathan, D., Reindle, A., Johnson, E.S., Berger, S.L. Biochemistry (2006)
- Increasing the rate of chromatin remodeling and gene activation--a novel role for the histone acetyltransferase Gcn5. Barbaric, S., Walker, J., Schmid, A., Svejstrup, J.Q., Hörz, W. EMBO J. (2001)
- GCN5-dependent histone H3 acetylation and RPD3-dependent histone H4 deacetylation have distinct, opposing effects on IME2 transcription, during meiosis and during vegetative growth, in budding yeast. Burgess, S.M., Ajimura, M., Kleckner, N. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Role for ADA/GCN5 products in antagonizing chromatin-mediated transcriptional repression. Pollard, K.J., Peterson, C.L. Mol. Cell. Biol. (1997)
- Human histone acetyltransferase GCN5 exists in a stable macromolecular complex lacking the adapter ADA2. Forsberg, E.C., Lam, L.T., Yang, X.J., Nakatani, Y., Bresnick, E.H. Biochemistry (1997)
- Genetic interactions between Nhp6 and Gcn5 with Mot1 and the Ccr4-Not complex that regulate binding of TATA-binding protein in Saccharomyces cerevisiae. Biswas, D., Yu, Y., Mitra, D., Stillman, D.J. Genetics (2006)
- The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiae. Eberharter, A., Sterner, D.E., Schieltz, D., Hassan, A., Yates, J.R., Berger, S.L., Workman, J.L. Mol. Cell. Biol. (1999)
- Mediator-nucleosome interaction. Lorch, Y., Beve, J., Gustafsson, C.M., Myers, L.C., Kornberg, R.D. Mol. Cell (2000)