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Gene Review

SBH2  -  Sbh2p

Saccharomyces cerevisiae S288c

Synonyms: Protein transport protein SBH2, SEB2, Ssh1 complex subunit SBH2, Ssh1 complex subunit beta, YER019BC, ...
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High impact information on SBH2

  • Sbh1p and Sbh2p individually are also not essential, but cells lacking both proteins are impaired in their growth at elevated temperatures and accumulate precursors of secretory proteins; microsomes isolated from these cells also exhibit a reduced rate of post-translational protein transport [1].
  • Moreover, the deletion of Spc2p also decreased the expression level of Sbh2p [2].

Biological context of SBH2

  • Disruption of the chromosomal SEB2 was not lethal whereas the double disruption of SEB1 and SEB2 resulted in a temperature-sensitive phenotype [3].

Analytical, diagnostic and therapeutic context of SBH2


  1. A second trimeric complex containing homologs of the Sec61p complex functions in protein transport across the ER membrane of S. cerevisiae. Finke, K., Plath, K., Panzner, S., Prehn, S., Rapoport, T.A., Hartmann, E., Sommer, T. EMBO J. (1996) [Pubmed]
  2. Interactions between Spc2p and other components of the endoplasmic reticulum translocation sites of the yeast Saccharomyces cerevisiae. Antonin, W., Meyer, H.A., Hartmann, E. J. Biol. Chem. (2000) [Pubmed]
  3. Yeast protein translocation complex: isolation of two genes SEB1 and SEB2 encoding proteins homologous to the Sec61 beta subunit. Toikkanen, J., Gatti, E., Takei, K., Saloheimo, M., Olkkonen, V.M., Söderlund, H., De Camilli, P., Keränen, S. Yeast (1996) [Pubmed]
  4. Sbh1p, a subunit of the Sec61 translocon, interacts with the chaperone calnexin in the yeast Yarrowia lipolytica. Boisramé, A., Chasles, M., Babour, A., Beckerich, J.M., Gaillardin, C. J. Cell. Sci. (2002) [Pubmed]
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