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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PEA2  -  Pea2p

Saccharomyces cerevisiae S288c

Synonyms: DFG9, PPF2, Protein PEA2, Protein PPF2, YER149C
 
 
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High impact information on PEA2

  • We previously identified mutants defective in PEA2 and SPA2 which alter cell polarization in the presence of mating pheromone in a similar manner (Chenevert, J., N. Valtz, and I. Herskowitz. 1994. Genetics, 136:1287-1297) [1].
  • Velocity sedimentation experiments suggest that a significant portion of Spa2p, Pea2p, and Bud6p cosediment, raising the possibility that these proteins form a large, 12S multiprotein complex [2].
  • These results indicate that PPF2 and PPF3 are involved in the response to alpha-factor at high concentrations and that PPF3 is also required for proper establishment of polarity in vegetative growth [3].
 

Physical interactions of PEA2

  • One of the regions involved in Spa2p stability and localization interacts with Pea2p; this region contains a conserved domain, SHD-II [2].
 

Other interactions of PEA2

References

  1. Pea2 protein of yeast is localized to sites of polarized growth and is required for efficient mating and bipolar budding. Valtz, N., Herskowitz, I. J. Cell Biol. (1996) [Pubmed]
  2. Spa2p interacts with cell polarity proteins and signaling components involved in yeast cell morphogenesis. Sheu, Y.J., Santos, B., Fortin, N., Costigan, C., Snyder, M. Mol. Cell. Biol. (1998) [Pubmed]
  3. Saccharomyces cerevisiae MATa mutant cells defective in pointed projection formation in response to alpha-factor at high concentrations. Yorihuzi, T., Ohsumi, Y. Yeast (1994) [Pubmed]
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