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Gene Review

PEA2  -  Pea2p

Saccharomyces cerevisiae S288c

Synonyms: DFG9, PPF2, Protein PEA2, Protein PPF2, YER149C
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High impact information on PEA2

  • We previously identified mutants defective in PEA2 and SPA2 which alter cell polarization in the presence of mating pheromone in a similar manner (Chenevert, J., N. Valtz, and I. Herskowitz. 1994. Genetics, 136:1287-1297) [1].
  • Velocity sedimentation experiments suggest that a significant portion of Spa2p, Pea2p, and Bud6p cosediment, raising the possibility that these proteins form a large, 12S multiprotein complex [2].
  • These results indicate that PPF2 and PPF3 are involved in the response to alpha-factor at high concentrations and that PPF3 is also required for proper establishment of polarity in vegetative growth [3].

Physical interactions of PEA2

  • One of the regions involved in Spa2p stability and localization interacts with Pea2p; this region contains a conserved domain, SHD-II [2].

Other interactions of PEA2


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