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Gene Review

PPAP2C  -  phosphatidic acid phosphatase type 2C

Homo sapiens

Synonyms: LPP2, Lipid phosphate phosphohydrolase 2, PAP-2c, PAP2-G, PAP2-g, ...
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High impact information on PPAP2C

  • These effects of LPP2 activity were not reproduced by overexpression or knock-down of LPP1 or LPP3 [1].
  • This work identifies a novel and specific role for LPP2 activity and bioactive lipids in regulating cell cycle progression [1].
  • Additionally, arrested LPP2 cells contained decreased lysophosphatidate concentrations and increased ceramide [1].
  • We report the cloning and expression of a third type 2 PAP enzyme (288 amino acids, predicted molecular mass of 32.6 kDa), PAP-2c, which exhibits 54 and 43% sequence homology to PAPs 2a and 2b [2].
  • Other significant differences between gpPAP2a1/2 and hPAP2a, hPAP2b and hPAP2c occur at the cytoplasmic C-terminal [3].

Other interactions of PPAP2C

  • Km values for each of the substrates, respectively, were (in microM) PAP-2a: 98, 170, 116; PAP-2b: 100, 110, 56; and PAP-2c: 150, 340, 138 [4].

Analytical, diagnostic and therapeutic context of PPAP2C


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