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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PPAP2C  -  phosphatidic acid phosphatase type 2C

Homo sapiens

Synonyms: LPP2, Lipid phosphate phosphohydrolase 2, PAP-2c, PAP2-G, PAP2-g, ...
 
 
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High impact information on PPAP2C

  • These effects of LPP2 activity were not reproduced by overexpression or knock-down of LPP1 or LPP3 [1].
  • This work identifies a novel and specific role for LPP2 activity and bioactive lipids in regulating cell cycle progression [1].
  • Additionally, arrested LPP2 cells contained decreased lysophosphatidate concentrations and increased ceramide [1].
  • We report the cloning and expression of a third type 2 PAP enzyme (288 amino acids, predicted molecular mass of 32.6 kDa), PAP-2c, which exhibits 54 and 43% sequence homology to PAPs 2a and 2b [2].
  • Other significant differences between gpPAP2a1/2 and hPAP2a, hPAP2b and hPAP2c occur at the cytoplasmic C-terminal [3].
 

Other interactions of PPAP2C

  • Km values for each of the substrates, respectively, were (in microM) PAP-2a: 98, 170, 116; PAP-2b: 100, 110, 56; and PAP-2c: 150, 340, 138 [4].
 

Analytical, diagnostic and therapeutic context of PPAP2C

References

  1. Lipid phosphate phosphatase-2 activity regulates S-phase entry of the cell cycle in Rat2 fibroblasts. Morris, K.E., Schang, L.M., Brindley, D.N. J. Biol. Chem. (2006) [Pubmed]
  2. Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform. Roberts, R., Sciorra, V.A., Morris, A.J. J. Biol. Chem. (1998) [Pubmed]
  3. Molecular cloning of magnesium-independent type 2 phosphatidic acid phosphatases from airway smooth muscle. Tate, R.J., Tolan, D., Pyne, S. Cell. Signal. (1999) [Pubmed]
  4. Identification of a novel human phosphatidic acid phosphatase type 2 isoform. Hooks, S.B., Ragan, S.P., Lynch, K.R. FEBS Lett. (1998) [Pubmed]
  5. Molecular cloning and expression of pulmonary lipid phosphate phosphohydrolases. Nanjundan, M., Possmayer, F. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]
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