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Gene Review

PPAP2B  -  phosphatidic acid phosphatase type 2B

Homo sapiens

Synonyms: Dri42, LPP3, Lipid phosphate phosphohydrolase 3, PAP-2b, PAP2-beta, ...
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High impact information on PPAP2B


Biological context of PPAP2B


Anatomical context of PPAP2B


Associations of PPAP2B with chemical compounds


Other interactions of PPAP2B

  • The pulmonary LPP1 and LPP3 isoforms are essentially identical to the previously cloned rat liver and intestinal LPPs, respectively, and the LPP1a isoform has 80% sequence identity to the human homolog [4].
  • Km values for each of the substrates, respectively, were (in microM) PAP-2a: 98, 170, 116; PAP-2b: 100, 110, 56; and PAP-2c: 150, 340, 138 [11].
  • The effects of hLPP-3 on colony-forming activity were substantially reversed by the LPP-resistant LPA analogue, O-methylphosphothionate [2].

Analytical, diagnostic and therapeutic context of PPAP2B

  • The RT-PCR generated LPP1 (849 bp), up to three LPP1 variants, and LPP3 (936 bp) cDNAs [4].
  • Strikingly, coculture of hLPP-3-expressing cells with nontransfected parental cells decreased the colony-forming activity of the parental cells, compatible with hLPP-3 decreasing levels of an extracellular mediator, likely LPA [2].
  • GST-mLpp3-RGE interacted with alpha(5)beta(1) and alpha(v)beta(3) integrins in a solid-phase ELISA, while a mutant control, GST-hLPP3-RAD, did not [12].


  1. Regulation of cell-cell interactions by phosphatidic acid phosphatase 2b/VCIP. Humtsoe, J.O., Feng, S., Thakker, G.D., Yang, J., Hong, J., Wary, K.K. EMBO J. (2003) [Pubmed]
  2. The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer. Tanyi, J.L., Morris, A.J., Wolf, J.K., Fang, X., Hasegawa, Y., Lapushin, R., Auersperg, N., Sigal, Y.J., Newman, R.A., Felix, E.A., Atkinson, E.N., Mills, G.B. Cancer Res. (2003) [Pubmed]
  3. Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase. Kai, M., Wada, I., Imai, S., Sakane, F., Kanoh, H. J. Biol. Chem. (1997) [Pubmed]
  4. Molecular cloning and expression of pulmonary lipid phosphate phosphohydrolases. Nanjundan, M., Possmayer, F. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]
  5. Sequential actions of phospholipase D and phosphatidic acid phosphohydrolase 2b generate diglyceride in mammalian cells. Sciorra, V.A., Morris, A.J. Mol. Biol. Cell (1999) [Pubmed]
  6. Cell surface activities of the human type 2b phosphatidic acid phosphatase. Ishikawa, T., Kai, M., Wada, I., Kanoh, H. J. Biochem. (2000) [Pubmed]
  7. Anti-lipid phosphate phosphohydrolase-3 (LPP3) antibody inhibits bFGF- and VEGF-induced capillary morphogenesis of endothelial cells. Wary, K.K., Humtsoe, J.O. Cell communication and signaling [electronic resource] : CCS. (2005) [Pubmed]
  8. Differential localization of lipid phosphate phosphatases 1 and 3 to cell surface subdomains in polarized MDCK cells. Jia, Y.J., Kai, M., Wada, I., Sakane, F., Kanoh, H. FEBS Lett. (2003) [Pubmed]
  9. Lipid phosphate phosphatases 1 and 3 are localized in distinct lipid rafts. Kai, M., Sakane, F., Jia, Y.J., Imai, S., Yasuda, S., Kanoh, H. J. Biochem. (2006) [Pubmed]
  10. Enhanced apoptosis through farnesol inhibition of phospholipase D signal transduction. Taylor, M.M., Macdonald, K., Morris, A.J., McMaster, C.R. FEBS J. (2005) [Pubmed]
  11. Identification of a novel human phosphatidic acid phosphatase type 2 isoform. Hooks, S.B., Ragan, S.P., Lynch, K.R. FEBS Lett. (1998) [Pubmed]
  12. Murine lipid phosphate phosphohydrolase-3 acts as a cell-associated integrin ligand. Humtsoe, J.O., Bowling, R.A., Feng, S., Wary, K.K. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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