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Gene Review

EIF3F  -  eukaryotic translation initiation factor 3...

Homo sapiens

Synonyms: Deubiquitinating enzyme eIF3f, EIF3S5, Eukaryotic translation initiation factor 3 subunit 5, Eukaryotic translation initiation factor 3 subunit F, eIF-3-epsilon, ...
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Disease relevance of EIF3S5


High impact information on EIF3S5

  • In the present study, we investigate the biological function of eIF3f in translation and apoptosis in tumor cells [1].
  • Ribosome profile and ribosomal RNA (rRNA) fragmentation assays revealed that eIF3f reduces ribosomes, which may be associated with rRNA degradation [1].

Biological context of EIF3S5


  1. Decreased expression of eukaryotic initiation factor 3f deregulates translation and apoptosis in tumor cells. Shi, J., Kahle, A., Hershey, J.W., Honchak, B.M., Warneke, J.A., Leong, S.P., Nelson, M.A. Oncogene (2006) [Pubmed]
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