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Gene Review:

EIF3F - eukaryotic translation initiation factor 3...

Homo sapiens

Synonyms: Deubiquitinating enzyme eIF3f, EIF3S5, Eukaryotic translation initiation factor 3 subunit 5, Eukaryotic translation initiation factor 3 subunit F, eIF-3-epsilon, ...

Shi, J. et al.

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Disease relevance of EIF3S5

Silencing of eIF3f protects melanoma cells from apoptosis [1].
Overexpression of eIF3f inhibits cell proliferation and induces apoptosis in melanoma and pancreatic cancer cells [1].

High impact information on EIF3S5

In the present study, we investigate the biological function of eIF3f in translation and apoptosis in tumor cells [1].
Ribosome profile and ribosomal RNA (rRNA) fragmentation assays revealed that eIF3f reduces ribosomes, which may be associated with rRNA degradation [1].

Biological context of EIF3S5

We demonstrated for the first time that eIF3f is downregulated in most human tumors using a cancer profiling array and confirmed by real-time reverse transcription PCR in melanoma and pancreatic cancer [1].

References

Decreased expression of eukaryotic initiation factor 3f deregulates translation and apoptosis in tumor cells. Shi, J., Kahle, A., Hershey, J.W., Honchak, B.M., Warneke, J.A., Leong, S.P., Nelson, M.A. Oncogene (2006) [Pubmed]

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EIF3F_ANOGA	Anopheles gambiae str. PEST
EIF2	Arabidopsis thaliana
EIF3F	Bos taurus
eif-3.F	Caenorhabditis elegans
EIF3F	Canis lupus familiaris
eif3f	Danio rerio
CG9769	Drosophila melanogaster
EIF3F	Gallus gallus
EIF3F	Macaca mulatta
MGG_10653	Magnaporthe oryzae 70-15
Eif3f	Mus musculus
NCU01021	Neurospora crassa OR74A
Os05g0104800	Oryza sativa Japonica Group
EIF3F	Pan troglodytes
Eif3f	Rattus norvegicus
SPBC4C3.07	Schizosaccharomyces pombe 972h-
eif3f	Xenopus (Silurana) tropicalis

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