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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Reverse Transcription

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Disease relevance of Reverse Transcription


High impact information on Reverse Transcription


Chemical compound and disease context of Reverse Transcription


Biological context of Reverse Transcription


Anatomical context of Reverse Transcription


Associations of Reverse Transcription with chemical compounds

  • The IVS1-containing RNA processing products have several unusual properties, which include: anomalous electrophoretic mobilities on polyacrylamide gels; a block to reverse transcription near the 3' end of IVS1; the presence of a nuclease-resistant component within IVS1 [26].
  • Analysis of 5-bromodeoxyuridine-labeled heavy/light CCC DNA shows that the relaxed circular DNA synthesized in the cytoplasm by reverse transcription is the predominant precursor to the amplified pool of nuclear viral CCC DNA [27].
  • In vivo and in vitro studies revealed that reverse transcription of viral RNA into complementary DNA occurred after acute infection of cells of its natural hosts, mouse and hamster, but not of other species and could be inhibited in vitro by azidothymidine (AZT), indicating that this was mediated by endogenous reverse transcriptase activity [28].
  • The transposition defect results from Mn(2+) accumulation that inhibits reverse transcription [29].
  • Inhibition of reverse transcription in vivo by elevated manganese ion concentration [29].

Gene context of Reverse Transcription


Analytical, diagnostic and therapeutic context of Reverse Transcription


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