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Gene Review

JMJD7-PLA2G4B  -  JMJD7-PLA2G4B readthrough

Homo sapiens

Synonyms: HsT16992, cPLA2-beta
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High impact information on PLA2G4B

  • We have isolated a cDNA encoding a 1012-amino acid polypeptide cPLA2-beta, that has significant homology with cPLA2-alpha in both the calcium-dependent lipid binding domain as well as in the catalytic domain [1].
  • Case-control analyses revealed modest evidence (0.01 < P < 0.05) for association between a single variant in PLCB2 and two variants in PLA2G4B [2].


  1. Molecular characterization of cytosolic phospholipase A2-beta. Song, C., Chang, X.J., Bean, K.M., Proia, M.S., Knopf, J.L., Kriz, R.W. J. Biol. Chem. (1999) [Pubmed]
  2. Association analysis of two candidate phospholipase genes that map to the chromosome 15q15.1-15.3 region associated with reading disability. Morris, D.W., Ivanov, D., Robinson, L., Williams, N., Stevenson, J., Owen, M.J., Williams, J., O'Donovan, M.C. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2004) [Pubmed]
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