The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PLA2G4A  -  phospholipase A2, group IVA (cytosolic,...

Homo sapiens

Synonyms: CPLA2, Cytosolic phospholipase A2, PLA2G4, Phospholipase A2 group IVA, cPLA2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PLA2G4A


Psychiatry related information on PLA2G4A


High impact information on PLA2G4A


Chemical compound and disease context of PLA2G4A


Biological context of PLA2G4A


Anatomical context of PLA2G4A


Associations of PLA2G4A with chemical compounds


Physical interactions of PLA2G4A


Enzymatic interactions of PLA2G4A


Regulatory relationships of PLA2G4A


Other interactions of PLA2G4A


Analytical, diagnostic and therapeutic context of PLA2G4A


  1. Association of a F479L variant in the cytosolic phospholipase A2 gene (PLA2G4A) with decreased glucose turnover and oxidation rates in Pima Indians. Wolford, J.K., Konheim, Y.L., Colligan, P.B., Bogardus, C. Mol. Genet. Metab. (2003) [Pubmed]
  2. Secretory phospholipase A2 activates the cascade of mitogen-activated protein kinases and cytosolic phospholipase A2 in the human astrocytoma cell line 1321N1. Hernández, M., Burillo, S.L., Crespo, M.S., Nieto, M.L. J. Biol. Chem. (1998) [Pubmed]
  3. Induction of cytosolic phospholipase A2 by oncogenic Ras in human non-small cell lung cancer. Heasley, L.E., Thaler, S., Nicks, M., Price, B., Skorecki, K., Nemenoff, R.A. J. Biol. Chem. (1997) [Pubmed]
  4. Cytosolic phospholipase A2 participates with TNF-alpha in the induction of apoptosis of human macrophages infected with Mycobacterium tuberculosis H37Ra. Duan, L., Gan, H., Arm, J., Remold, H.G. J. Immunol. (2001) [Pubmed]
  5. Differential role of cytosolic phospholipase A2 in the invasion of brain microvascular endothelial cells by Escherichia coli and Listeria monocytogenes. Das, A., Asatryan, L., Reddy, M.A., Wass, C.A., Stins, M.F., Joshi, S., Bonventre, J.V., Kim, K.S. J. Infect. Dis. (2001) [Pubmed]
  6. BanI polymorphism of the cytosolic phospholipase A2 gene and mood disorders in the Korean population. Pae, C.U., Yu, H.S., Kim, J.J., Lee, C.U., Lee, S.J., Lee, K.U., Jun, T.Y., Paik, I.H., Serretti, A., Lee, C. Neuropsychobiology (2004) [Pubmed]
  7. Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism. Dessen, A., Tang, J., Schmidt, H., Stahl, M., Clark, J.D., Seehra, J., Somers, W.S. Cell (1999) [Pubmed]
  8. cPLA2 is phosphorylated and activated by MAP kinase. Lin, L.L., Wartmann, M., Lin, A.Y., Knopf, J.L., Seth, A., Davis, R.J. Cell (1993) [Pubmed]
  9. A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP. Clark, J.D., Lin, L.L., Kriz, R.W., Ramesha, C.S., Sultzman, L.A., Lin, A.Y., Milona, N., Knopf, J.L. Cell (1991) [Pubmed]
  10. Cytosolic phospholipase A2 and the distinct transcriptional programs of astrocytoma cells. Hernández, M., Nieto, M.L., Sánchez Crespo, M. Trends Neurosci. (2000) [Pubmed]
  11. I-PLA(2) activation during apoptosis promotes the exposure of membrane lysophosphatidylcholine leading to binding by natural immunoglobulin M antibodies and complement activation. Kim, S.J., Gershov, D., Ma, X., Brot, N., Elkon, K.B. J. Exp. Med. (2002) [Pubmed]
  12. Signaling mechanisms involved in the activation of arachidonic acid metabolism in human astrocytoma cells by tumor necrosis factor-alpha: phosphorylation of cytosolic phospholipase A2 and transactivation of cyclooxygenase-2. Hernández, M., Bayón, Y., Sánchez Crespo, M., Nieto, M.L. J. Neurochem. (1999) [Pubmed]
  13. Inhibition of cytosolic phospholipase A2 mRNA expression: a novel mechanism for acetylsalicylic acid-mediated growth inhibition and apoptosis in colon cancer cells. Yu, H.G., Huang, J.A., Yang, Y.N., Luo, H.S., Yu, J.P., Meier, J.J., Schrader, H., Bastian, A., Schmidt, W.E., Schmitz, F. Regul. Pept. (2003) [Pubmed]
  14. Enhancement of prostaglandin E2 production by epidermal growth factor requires the coordinate activation of cytosolic phospholipase A2 and cyclooxygenase 2 in human squamous carcinoma A431 cells. Sato, T., Nakajima, H., Fujio, K., Mori, Y. Prostaglandins (1997) [Pubmed]
  15. Thromboxane synthesis is increased by upregulation of cytosolic phospholipase A2 and cyclooxygenase-2 in peripheral polymorphonuclear leukocytes during bacterial infection in childhood. Zaitsu, M., Hamasaki, Y., Nishimura, S., Matsuo, M., Fujita, I., Ishii, E. Am. J. Hematol. (2003) [Pubmed]
  16. Activation of cPLA2 is required for leukotriene D4-induced proliferation in colon cancer cells. Parhamifar, L., Jeppsson, B., Sjölander, A. Carcinogenesis (2005) [Pubmed]
  17. A study of a genetic association between the PTGS2/PLA2G4A locus and schizophrenia. Wei, J., Hemmings, G.P. Prostaglandins Leukot. Essent. Fatty Acids (2004) [Pubmed]
  18. A study of the combined effect of the CLDN5 locus and the genes for the phospholipid metabolism pathway in schizophrenia. Wei, J., Hemmings, G.P. Prostaglandins Leukot. Essent. Fatty Acids (2005) [Pubmed]
  19. Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases. Hefner, Y., Borsch-Haubold, A.G., Murakami, M., Wilde, J.I., Pasquet, S., Schieltz, D., Ghomashchi, F., Yates, J.R., Armstrong, C.G., Paterson, A., Cohen, P., Fukunaga, R., Hunter, T., Kudo, I., Watson, S.P., Gelb, M.H. J. Biol. Chem. (2000) [Pubmed]
  20. Cytosolic phospholipase A2 Group IValpha but not secreted phospholipase A2 Group IIA, V, or X induces interleukin-8 and cyclooxygenase-2 gene and protein expression through peroxisome proliferator-activated receptors gamma 1 and 2 in human lung cells. Pawliczak, R., Logun, C., Madara, P., Lawrence, M., Woszczek, G., Ptasinska, A., Kowalski, M.L., Wu, T., Shelhamer, J.H. J. Biol. Chem. (2004) [Pubmed]
  21. Involvement of cytosolic phospholipase A2 and secretory phospholipase A2 in arachidonic acid release from human neutrophils. Marshall, J., Krump, E., Lindsay, T., Downey, G., Ford, D.A., Zhu, P., Walker, P., Rubin, B. J. Immunol. (2000) [Pubmed]
  22. Cytosolic phospholipase A2 activation is essential for beta 1 and beta 2 integrin-dependent adhesion of human eosinophils. Zhu, X., Muñoz, N.M., Kim, K.P., Sano, H., Cho, W., Leff, A.R. J. Immunol. (1999) [Pubmed]
  23. Interleukin-1 beta induces cytosolic phospholipase A2 and prostaglandin H synthase in rheumatoid synovial fibroblasts. Evidence for their roles in the production of prostaglandin E2. Hulkower, K.I., Wertheimer, S.J., Levin, W., Coffey, J.W., Anderson, C.M., Chen, T., DeWitt, D.L., Crowl, R.M., Hope, W.C., Morgan, D.W. Arthritis Rheum. (1994) [Pubmed]
  24. Association of cPLA2-alpha and COX-1 with the Golgi apparatus of A549 human lung epithelial cells. Grewal, S., Ponnambalam, S., Walker, J.H. J. Cell. Sci. (2003) [Pubmed]
  25. Cyclooxygenase-2 induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a novel autocrine loop involving endogenous prostaglandin E2, E-prostanoid 2 (EP2), and EP4 receptors. Bradbury, D.A., Newton, R., Zhu, Y.M., El-Haroun, H., Corbett, L., Knox, A.J. J. Biol. Chem. (2003) [Pubmed]
  26. The role of TFIID, the initiator element and a novel 5' TFIID binding site in the transcriptional control of the TATA-less human cytosolic phospholipase A2-alpha promoter. Cowan, M.J., Yao, X.L., Pawliczak, R., Huang, X., Logun, C., Madara, P., Alsaaty, S., Wu, T., Shelhamer, J.H. Biochim. Biophys. Acta (2004) [Pubmed]
  27. Cytosolic phospholipase A2 is phosphorylated in collagen- and thrombin-stimulated human platelets independent of protein kinase C and mitogen-activated protein kinase. Börsch-Haubold, A.G., Kramer, R.M., Watson, S.P. J. Biol. Chem. (1995) [Pubmed]
  28. Transforming growth factor-beta (TGF-beta) activates cytosolic phospholipase A2alpha (cPLA2alpha)-mediated prostaglandin E2 (PGE)2/EP1 and peroxisome proliferator-activated receptor-gamma (PPAR-gamma)/Smad signaling pathways in human liver cancer cells. A novel mechanism for subversion of TGF-beta-induced mitoinhibition. Han, C., Demetris, A.J., Liu, Y., Shelhamer, J.H., Wu, T. J. Biol. Chem. (2004) [Pubmed]
  29. Interleukin-4 inhibits the gene expression and biosyntheis of cytosolic phospholipase A2 in lipopolysaccharide stimulated U937 macrophage cell line and freshly prepared adherent rheumatoid synovial cells. Kuroda, A., Sugiyama, E., Taki, H., Mino, T., Kobayashi, M. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  30. Interferon-gamma induces the synthesis and activation of cytosolic phospholipase A2. Wu, T., Levine, S.J., Lawrence, M.G., Logun, C., Angus, C.W., Shelhamer, J.H. J. Clin. Invest. (1994) [Pubmed]
  31. Selective inhibitors of cytosolic or secretory phospholipase A2 block TNF-induced activation of transcription factor nuclear factor-kappa B and expression of ICAM-1. Thommesen, L., Sjursen, W., Gåsvik, K., Hanssen, W., Brekke, O.L., Skattebøl, L., Holmeide, A.K., Espevik, T., Johansen, B., Laegreid, A. J. Immunol. (1998) [Pubmed]
  32. Regulation of prostaglandin production in intact fetal membranes by interleukin-1 and its receptor antagonist. Brown, N.L., Alvi, S.A., Elder, M.G., Bennett, P.R., Sullivan, M.H. J. Endocrinol. (1998) [Pubmed]
  33. Type IIA secretory phospholipase A2 up-regulates cyclooxygenase-2 and amplifies cytokine-mediated prostaglandin production in human rheumatoid synoviocytes. Bidgood, M.J., Jamal, O.S., Cunningham, A.M., Brooks, P.M., Scott, K.F. J. Immunol. (2000) [Pubmed]
  34. Inhibition of prostaglandin endoperoxide synthase-2 expression in stimulated human monocytes by inhibitors of p38 mitogen-activated protein kinase. Pouliot, M., Baillargeon, J., Lee, J.C., Cleland, L.G., James, M.J. J. Immunol. (1997) [Pubmed]
  35. Molecular characterization of cytosolic phospholipase A2-beta. Song, C., Chang, X.J., Bean, K.M., Proia, M.S., Knopf, J.L., Kriz, R.W. J. Biol. Chem. (1999) [Pubmed]
  36. Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells. Kargman, S., Wong, E., Greig, G.M., Falgueyret, J.P., Cromlish, W., Ethier, D., Yergey, J.A., Riendeau, D., Evans, J.F., Kennedy, B., Tagari, P., Francis, D.A., O'Neill, G.P. Biochem. Pharmacol. (1996) [Pubmed]
  37. Interleukin-4, transforming growth factor beta 1, and dexamethasone inhibit superantigen-induced prostaglandin E2-dependent collagenase gene expression through their action on cyclooxygenase-2 and cytosolic phospholipase A2. Mehindate, K., al-Daccak, R., Aoudjit, F., Damdoumi, F., Fortier, M., Borgeat, P., Mourad, W. Lab. Invest. (1996) [Pubmed]
  38. Molecular cloning and expression of human Ca(2+)-sensitive cytosolic phospholipase A2. Sharp, J.D., White, D.L., Chiou, X.G., Goodson, T., Gamboa, G.C., McClure, D., Burgett, S., Hoskins, J., Skatrud, P.L., Sportsman, J.R. J. Biol. Chem. (1991) [Pubmed]
  39. Regulation of synoviocyte phospholipase A2 and cyclooxygenase 2 by macrophage migration inhibitory factor. Sampey, A.V., Hall, P.H., Mitchell, R.A., Metz, C.N., Morand, E.F. Arthritis Rheum. (2001) [Pubmed]
  40. Cytoplasmic phospholipase A2 expression in human colon adenocarcinoma is correlated with cyclooxygenase-2 expression and contributes to prostaglandin E2 production. Panel, V., Bo??lle, P.Y., Ayala-Sanmartin, J., Jouniaux, A.M., Hamelin, R., Masliah, J., Trugnan, G., Fl??jou, J.F., Wendum, D. Cancer Lett. (2006) [Pubmed]
  41. Stimulation-dependent recruitment of cytosolic phospholipase A2-alpha to EA.hy.926 endothelial cell membranes leads to calcium-independent association. Grewal, S., Smith, J., Ponnambalam, S., Walker, J. Eur. J. Biochem. (2004) [Pubmed]
  42. Presence of secretory group IIa and V phospholipase A2 and cytosolic group IValpha phospholipase A2 in chondrocytes from patients with rheumatoid arthritis. Leistad, L., Feuerherm, A.J., Ostensen, M., Faxvaag, A., Johansen, B. Clin. Chem. Lab. Med. (2004) [Pubmed]
WikiGenes - Universities